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I think it would only be a "key" to chronic fatigue syndrome if it were very specific to ME/CFS patients as well as a common finding in ME/CFS patients. I've certainly experienced visual problems that I connect to ME - mainly related to difficulties with convergrance and "fusion" of the stereo...

A question I’ve never really thought of before is… if you get delayed PEM (next day PEM) does it gradually begin to improve on that day, or does it only begin to improve after another sleep cycle? I would say the latter. [I’m not saying it will fully resolve after another period of sleep, just...

Another alternative would be rechargeable, wireless speaker(s). These have the advantage of not being tethered to the laptop (assuming it can transmit a wireless signal), but you do need to recharge them every once in a while (via USB). Unless laptop internal speakers have improved greatly, a...

There's something called the (deep breath) "MagicHold Height Adjusting Sit Stand Computer,Monitor,Laptop,Tablet for Bed Office Stand Mount Workstation" - which is currently unavailable at Amazon. It has "mixed" reviews, but it is intended as a way to use a desktop PC in bed. It looks like the PC...

This is a good video, but am I the only one who can't believe that the host, Hank Green, is 41 years old? :)

I think you're right and that there are a lot of different types of balance disorders and the nomenclature often seems to overlap and lack precision. I have had "Benign Paroxysmal Positional Vertigo" (BPPV) (otolith disease) on several occasions in my 30's and it was initially totally disabling...

So I assume the controls are going to have to go through all the exercise and the biological sampling also, because who knows what that stress does to protein levels even when you're healthy. Those will have to be pretty dedicated controls to sign up for two muscle biopsies a week apart as well...

It might be interesting to see if those with post-exertional fatigue following brain injury show the same post-exertional increases in sensory, adrenergic and immune gene expression that ME/CFS patients do after exercise. In Alan Light's 2009 paper, "Moderate exercise increases expression for...

Merged thread "Voices of Long COVID" (video/radio campaign) I just heard a spot on the radio called "Voices of Long COVID" which lead me to their website here: https://voicesoflongcovid.org/ It seems to be a collection of interviews with relatively young people (ages 20 to 26) who describe...

You'll get no argument from me. This is why I included the caveat, "unless that condition can also be triggered by an immune challenge." :)

Though it does not pertain to all cases of ME/CFS, one thing that Long Covid has made clear is that an ME-like illness can develop as a post-infectious condition. So, if ME occurs in the wake of some kind of infection, I would think that would provide fairly strong evidence that the infection...

It could simply mean ME/CFS with the known precursor of Covid-19 infection. The ME/CFS component might be the same, while other post-Covid problems, like lung injury, distinguish it from "types" of ME/CFS brought on by other kinds of infections / conditions.

From what I can tell, the previous Director of the Office of Science and Technology Policy (OSTP), Eric Lander, recently left the office after only about six months on the job. He had been accused by more than a dozen persons of having "bullied" and "demeaned" his subordinates. In the past, the...

I got "pay-walled" before I could read much of the article. It would be interesting to know if they discussed PEM, particularly delayed PEM. I believe they mentioned that "exercise made some patients worse," but I didn't see anything on when patients felt worse. Dr. Komaroff has said in the...

NATURE (02/02/2022) Decade-long leukaemia remissions with persistence of CD4+ CAR T cells J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen, McKensie A. Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici...

There have been a couple papers indicating that respiratory infection (in mice) alters the gut microbiome. 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816042/ 2020 https://journals.asm.org/doi/10.1128/mBio.03236-19 The more recent paper found that this alteration was actually caused by...

Since, depending upon the dosage, up to 32% of patients experience nausea with vortioxetine (vs. 9% with placebo), I'm not sure exactly how "blinded" the trial could be. I briefly took a TCA (supposedly to address my dizziness) which sent my pulse to 130 bpm 24 hours a day. Were it a trial, I'd...

There seems to be the suggestion that lower serum levels of IgG3 (and lower IgM levels) may be an important factor in the development of Long Covid. One of the strongest predictors of Long Covid in this study was a history of bronchial asthma (Odds Ratio 9.74 - pValue 0.003). [My Bold] [My...

A quick search seems to indicate that people with Munchausen's are aware that they are lying, but that they are also unable to keep themselves from doing so. Admitting, perhaps regretting, an antisocial compulsion in a diary seems pretty common in drama, at least. I not sure how often it happens...

So, if this lead to inadequate vasodilation in the microcirculation (perhaps while under the "load" of exercise) might it lead to effects like the arteriovenous "shunting" that Dr. Systrom has hypothesized? Also, I don't know if you wind up with "vasoconstriction" when vasodilation is...