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Would be good to know more about this. The blurb from ME Research UK implies that they were able to detect a difference between ME and MS, though I should add that a statistically significant difference between groups does not necessarily mean the test can differentiate in a clinically useful...

It’s just CBT with some quackery on top.

This sounds much more prone to bias than what they used in the CODES trial which was seizure frequency.

It's good they were able to use an MS control group. https://www.meresearch.org.uk/me-research-uk-and-the-me-association-announce-funding-for-a-study-that-aims-to-create-a-diagnostic-test-for-me-cfs/

Some more background from the comment section of the above article:

Chances of this being true = 0%

Carson https://x.com/alancarson15/status/1755477162226770005 “Interesting trial- once again showing rehabilitative exercise is beneficial in fatigue states- there comes a point where @NICEComms is going to have to recognise the harm their anti- scientific guidance is doing”

I know of a case who had ME/CFS and fibromyalgia for 20+ years, got cancer, received cyclo and was unexpectedly cured of ME/CFS in the process. This was years before the Norwegian rituximab and cyclo studies so probably not placebo/expectation bias. However, the symptoms returned 18 months...

Unclear why they thought this was ME/CFS. Typical geriatric depression presentation tbh.

Abstract Objective: This study assesses response to intravenous immunoglobulin (IVIG) in presumed autoimmune postural orthostatic tachycardia syndrome (POTS). Background: POTS may be associated with autoimmune disorders, serum autoantibodies, or recent infection. Uncontrolled case studies...

It’s typical pseudoimmunology you see in psychiatry papers, all their papers are like this.

You took the words right out of my mouth. This feeling was like nothing I had ever experienced and it was accompanied by a sense of something being profoundly wrong, doom. There’s no conventional vocabulary that can explain it. It’s not tiredness, fatigue, malaise, or any of this. It also had...

Rituximab as an adjunctive treatment for schizophrenia spectrum disorder or obsessive-compulsive disorder: Two open-label pilot studies on treatment-resistant patients https://www.sciencedirect.com/science/article/pii/S0022395622006719 Abstract In this explorative study, we investigated if an...

I’m surprised they chose 12 weeks as the primary endpoint.

The bone marrow transplant case is somewhat problematic because the donor with schizophrenia was his brother. Having a first-degree relative with scz is a strong risk factor for developing this heritable condition. However, first onset in 60s is unusual, though not unheard of. I’d be more...

Abstract Background The role of inflammation in the aetiology of schizophrenia has gained wide attention and research on the association shows an exponential growth in the last 15 years. Autoimmune diseases and severe infections are risk factors for the later development of schizophrenia...

Seeing the word tiredness in association with this condition makes me very angry but I suspect the reason this word is used is because the NHS website in general (not just the ME/CFS entry) is written in childlike language. Other NHS disease descriptions also use trivialising language like "sore...

Utterly misleading to imply that there is a single evidence-based treatment for this.