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I don't think this study tells us anything useful. You can't do a GWAS study with ~400 participants.

Same here, back in 2016 or so. The effect was dramatic, from housebound to being able to walk reasonably comfortably for an hour. I also noticed an immediate effect on muscle weakness: within 10-15 minutes of taking a high dose I could squat and get back up with ease, something I couldn't do at...

This 2007 study from the Journal of Psychosomatic Research to my mind suggests that retrospective subjective symptom reporting in MUS is useless. People seem to report what they think they know about themselves (personal semantic memory) rather than events they remember (episodic memory). Hard...

Very interesting.

It’s remarkable that the authors don’t consider, not even for a moment, that this could be anything other than suggestibility. What if FND is linked to autonomic dysfunction?

Pretty conclusive evidence of these antibodies not being the cause of our symptoms. The fact that this test is being sold to patients is a disgrace. (Btw I don’t know if others here experience this but sometimes I look at an old thread and am shocked to see a post I made that I don’t recall...

I suspect there is little to no outright fraud in CFS research because they know their work tends to be scrutinised with a fine tooth comb. They don’t need to fabricate data, though, to obtain desired results since they can just rig the outcome by using laughably biased outcome measures.

Stumbled on this old paper on nonepileptic seizures (FND) and tilt table test. Head-up tilting is a useful provocative test for psychogenic non-epileptic seizures

So true. Any language such as complex, multifactorial etc is a HUGE red flag. It means “needs psych referral”.

The issue with this paper is that you have to accept the premise that pts with ME/CFS have beta adrenergic autoantibodies. This is frequently asserted but as far as I can tell totally unproven. There are papers from German researchers claiming this as far back as 2013 or so. If it’s so...

Unfortunately these words don’t mean anything. They don’t add up to a coherent scientific mechanism.

That quote shocked me too. Since nothing is known about mechanisms of FM and Long Covid I wonder if he meant to say that even in the hypothetical future when we know a lot, the treatments could still be far off. It’s understandable that they are trying to dampen patient enthusiasm. It’s an...

The abstract is amazing in its deception. There was no significant time x group interaction on any outcome measure. This is the relevant result in such a study design. The correct interpretation is that the treatment did not work. But the conclusion is worded in a similar way to the PACE long...

Looks like another scam.

Sure, let’s say you have two groups, patients and controls, and you're interested in whether they differ on some outcome you're measuring in your study (e.g. antibody, score on a fatigue questionnaire etc.). The usual approach to this problem (you'll see this in every published paper) is to do a...

In statistics, an effect size is a number measuring the strength of the relationship between two variables in a population https://en.wikipedia.org/wiki/Effect_size

Yep. From the outset they are weeding out people who aren't suggestible by using prescreening questionnaires, looking for people who are high in personality traits agreeableness (going along to get along) and openness to experience. These sorts of people are willing to try reckless, random...

Going in an randomly editing parts of the genome will probably end up having lots of unintended consequences, such as maiming and killing ppl.