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He also refers to Paolo Maccalini's meta-analysis of DecodeME with results from other genetic databases. Not sure if we discussed this before. Looks like impressive work from Paolo. https://github.com/paolomaccallini-hub/MetaME

Made a thread on the Astrazeneca analysis here: https://www.s4me.info/threads/astrazeneca-phewas-analysis-using-the-uk-biobank.50076/

If we focus on the ME/CFS category that had the clearest result: 8 out of 2547 (0.31%) had one of the mutations that disrupted BTN2A1. But this was significantly more than the 50/121,923 (0.04%) in the control group. This page shows the DNA mutations...

There are multiple ways to identify ME/CFS patients in the UK Biobank, as explained in this paper: Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank - PMC Looks like there was also an increased odds ratio for BTN2A1 in the G93.3 ICD diagnosis...

The methods of the Astrazeneca analysis are explained in this 2021 paper: Wang et al. 2021. Rare variant contribution to human disease in 281,104 UK Biobank exomes | Nature

Chris Ponting mentioned this in this thread: https://www.s4me.info/threads/genetics-chromosome-6-btn2a2-and-btn3a3-btn2a1.45503/post-689176 The result can be viewed here...

Would be my guess: there are many more ways to mess things up than ways to make something work. But you're right that we're not sure of this.

What I don't quite get: ME/CFS symptoms suggest a disease of T-cell activation BTN2A1 is involved in activating the T-cell ME/CFS patients are more likely to have defective BTN2A1 So that doesn't fit with T-cells being overactive after all? Rather it suggests that at certain times the T-cells...

That's really interesting, thanks. Perhaps someone should make a separate thread on this? There are multiple ways to identify ME/CFS patients in the UK biobank as explained here: Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank - PMC Looks like...

Older study from 2007, some quotes that might be relevant to ME/CFS research:

Abstract Whereas biomedical products are required to be tested for safety with respect to vulnerable organ systems, psychosocial treatments are not required to be tested for safety with respect to vulnerable social systems such as the family. This article provides some evidence for the need to...

As I understand it, the consortium leaders are the problem. Think there was some reasonable biomedical research under this project but wonder how those researchers think about the statements by Liira that they pretty much found nothing. That didn't sound very respectful. It's not that you'll...

You can find that progress report on this page: https://cordis.europa.eu/project/id/101057553/results Decision support for prediction and management of Long Covid Syndrome (LCS) -> Results -> Deliverables -> Documents, reports (12) -> Results of the AIR trial.

No the progress report was submitted to the EU last year already. I just had a closer look at it following the protest and then the statements made in the article in L'Express.

True, but it sounds as if they themselves think the results won't change and the control group is doing slightly better on each of these preliminary outcomes. Found it remarkable given that the consortium leaders were arguing that biological studies only lead to null results and that a...

Agree, confirmed in this trial registration and supplementary material of the protocol. https://clinicaltrials.gov/study/NCT05212467 But it's strange that this study on Long Covid is doing a large trial that includes other patients as well (fibromyalgia prevalence is like 2-4%). The EU grant...

Looks like the authors shared preliminary results in this document to the EU (see attachment). There were no significant group differences for the three main outcomes. This is from a preliminary analysis that includes only 215 out of necessary 270 patients but the report writes that "there is...

Looks like this is funded by the EU grant on Long Covid: Here's the link to the EU page on the project which received 6.5 million in funding. Decision support for prediction and management of Long Covid Syndrome (LCS) | Long Covid | Project | Fact Sheet | HORIZON | CORDIS | European Commission...

Thanks @forestglip Used AI to screen these genes on function and these two might be interesting: ITGAE - facilitates adhesion of T-lymphocytes to epithelial cell TECPR2 - aids in the formation of autophagosomes

Made this summary of the paper: 1) Trigger warning: suicide This paper analyzed 505 entries on the National CFIDS Foundation memorial list. These were people with ME/CFS who passed away. The messages summarize their life, illness and struggles. The researchers grouped these into several...