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So what kind of experiments could get us from this point to a point where we understand more specifics about a potential gdT cell mechinism? Also, if the issue is BTN2A1 mediated T cell pathology, could this kind of monoclonal antibody be a potential drug? I can only see it being used in lab...

That an interesting idea. Epithelial cells came up the other day in a discussion on this genetics paper: Say the problem is as you hypothesised above - how would we test for it? Are there advanced PET scans that could detect this kind of pathology? Or is it just a 'collect enough evidence to...

The 'resigning in disgrace in 5-10 years time' conference

Yes but literature also is in love with the idea of psychosomatic illness and Freudian theory.

What results is that? A legacy of shoddy papers that don't stand up to scrutiny and people who can no longer care for themselves and are abandoned? These people have no shame.

Yeah I certainly didn't see the flaws and obfuscations in BPS logic until it was far too late. It's very compelling at first glance, especially for someone with a humanities background who's understanding of medical science and psychology is through popular memes and therapy sessions and having...

Found a few from a quick search:

There's been some discussion about calcium on here recently iirc, I think in the context of Type 1 interferons and mtDNA and all that but I could be misremembering.

Oh right- I've heard of a worsening through someone in an LC group but it could be the same person, I didn't talk to them directly or get any details.

That could maybe link to the vascular symptoms many people get, and/or JEs 'writing on the walls' concept

But it uses the wrong kind of AI - the actually useful kind!

Yeah that sounds about right. perhaps the people they're getting in to help with funding using the first amount of SequenceME will figure out how to pitch it to the Silicon Valley crowd.

That is a very interesting idea, no idea if it's mechinistically plausible. i know dmissa has been pretty emphatic that we can't build theories on his finding until its confirmed in fresh cells though. All this t cell stuff is really intriguing. I really wish we could just try some t cell...

The question is, aside from SequenceME, how do we look into this futher in a similar way to how the UCL researchers are planning to investigate CA10?

This is the thing that I'm wondering is how do we pitch SequenceME or F&Ms studies or the other good underfunded stuff so that these people see the potential for a breakthrough. As far as I can tell Polybios pitch is just 'find virus, make virus go away'. Which maybe is it's power. But why...

Possibly relevant - 'Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells' https://www.science.org/doi/10.1126/science.aay5516

Interesting! I seem to remember @forestglip attempting to tease out a possible link between MECFS and lupus from the genetic data late last year but I wasn't able to find the posts just now.

This is maybe a silly thought but should we have a thread of areas of biology/physiology that meet this criteria that could be worth having a think about? People could post papers and if anything deserves its own thread it could sort of branch off. Just a thread for kicking around ideas of 'oh...

I do get a little bit frustrated seeing Polybio get all this money just falling into their laps whilst brilliant MECFS researchers are having to go around hat in hand begging for funding. They don't seem to do a lot of immune research that doesn't revolve around viral persistence, which imo is...