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I was emailing with the second author, Derek Jacoby. He is in fact working with Piyush. He says they have just recently presented this paper at the BioSMART conference in Paris, and they hope within the next few weeks that a peer-reviewed version will be published. He confirmed that, though the...

Preprint - Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running, 2025, Lingitz et al The antimicrobial peptides Calprotectin and beta defensin 2 were significantly increased in both marathoners and half-marathoners immediately after...

Now published: Link | PDF

Comparison of T-cell Receptor Diversity of people with Myalgic Encephalomyelitis versus controls, 2023, Dibble, Ponting et al

Thread: Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study, 2023, Chang et al Various antibiotics appeared to decrease risk of the fatiguing conditions. Everything they tested except Clarithromycin. Though the sample size is small for these...

This might be useful. Though while the thread is about trigger infections, I don't think they were necessarily testing them for pathogens during onset, but later when the condition was established, so I'm not sure if there's a better thread. This correspondence from John Chia and his son Andrew...

They tested a few antimicrobial peptides in sedentary controls, half-marathoners, and marathoners at baseline, immediately after the run, and 2-7 days after the run (only baseline for controls). Two peptides, calprotectin (S100A8/S100A9) and human beta-defensin 2 (hBD-2) were clearly elevated in...

Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running Marie-Therese Lingitz, Hannes Kühtreiber, Lisa Auer, Michael Mildner, Claus G. Krenn, Clemens Aigner, Bernhard Moser, Christine Bekos, Hendrik Jan Ankersmit [Line breaks added]...

I don't think that GitHub page is related, even though they link to it. I think it's just a user named mobius. It includes things related to playstation emulators and Star Wars and has existed for at least 12 years.

I don't think it's the same person based on the photo too: https://theorg.com/org/hack-club/org-chart/piyush-acharya

The lead author, Piyush Acharya, seems to be in high school. A news article says he was in 10th grade in Jan 2024. He apparently started a non-profit called DNanalyzer three years ago. The GitHub page says "Supported by Anthropic. [...] Our impact has been recognized by Y Combinator, the...

There's a whole fancy website showing off the model and recommending clinicians to use it in their practice: https://mobius.dnanalyzer.org/ It includes some findings not included in the preprint:

I have no idea what to do with it, but just noting that it looks like they shared all the raw methylation data for the hundreds of participants (sourced from 14 other studies): https://huggingface.co/datasets/VerisimilitudeX/EpiMECoV

97.06% accuracy is very high. One thing is that all ME/CFS samples were pre-pandemic, so some of the difference between ME/CFS and LC might be related to time of sampling. But to not misclassify any samples between HC and disease is striking. It implies there were virtually no misdiagnoses in...

It's hard for me to read likely in that way. Wouldn't 'potentially', 'might', or 'may' make sense like these other bits that seem to be said in the same context? 'Some of these antibodies might fulfil a ‘broadly neutralising’ role' The suggestion is that FcγRI may fulfil (amongst other things)...

I'm not sure if it was the intention, but this comes across as confident that IFNG is related to symptoms. Extraneous parenthesis at the start.

It's now pretty clear that this was going on for me for years before I developed full blown disabling ME/CFS. I look back at a vacation I took about 6 years prior to onset, where I was excited and feeling great at the beginning and just kept decreasing in function over a couple weeks. I kept...

Maybe this could be another reference, though hard to know if the association is more with duration or severity. Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome (Sato et al, 2021)

For completeness, I'll add that the Swedish Dr. Gottfries in Sweden said he had an influx of patients in the 1950s during the "asian flu" H2N2 pandemic. https://s4me.info/threads/immune-stimulation-by-vaccination-e-g-staphylococcus-toxoid-vaccine-bcg.41358/#post-568807 Though I'm not sure he...

One thing I didn't mention in the above post, out of an abundance of statistical caution: When I first ran the GSEA on the Genebass dataset with the 52 clusters that were returned by STRING for the HEAL2 genes, I noticed that only 33 gene sets were tested in the analysis. I remembered that the...