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Well they're basically models trained in different ways, pulling out different genes. If they included some other third random ML model that also didn't do better than chance, that wouldn't make me more confident about the one that did. Isn't it possible that by chance one model returned genes...

I guess I'm not aware of the prior knowledge about these. HLA-C, there was the one HLA fine mapping study. But what was the evidence for synapses before this?

Is there a consensus? One thing for me: to lose virtually no accuracy on the test set (AUROC 0.677 to 0.670) makes me think there was a fair bit of randomness playing a part due to the size of the independent set, and it just happened to be high accuracy with this small group by chance. How...

https://www.crd.york.ac.uk/PROSPERO/view/CRD42024573955 If I'm reading the registration correctly, they did the searches in August 2024. Does anyone know a good reason you wouldn't include all studies up to the most recent available?

A lot of double negatives, but I think in general they're referring to actual decreases.

Graphic design student designing a campaign. Just skimmed the thesis, but here are some of the visuals:

Concept Campaign: Raising Awareness of ME/CFS Among Unaffected Audiences Iga Domińczuk LAB University of Applied Sciences Institute of Design and Fine Arts Bachelor of Culture and Arts, Packaging and Brand Design Abstract Visual communication has the power to challenge stigmas and public...

Effectiveness of Exercise-Based Rehabilitation in Chronic Fatigue Syndrome: A Systematic Review and Meta-analysis Antonio De Vera Martín, Alberto Díaz Salazar, Isidro Miguel Martín Pérez, Sebastián Eustaquio Martín Pérez [Line breaks added] Abstract Chronic Fatigue Syndrome is a complex and...

Ah now I understand! I replaced those acronyms in my post now.

Unfortunately, I don't think I could do a good job explaining it as I don't fully understand the paper. But a few bits: CBF is cerebral blood flow, or how much blood is flowing into the brain per minute. CO is cardiac output, or how much blood the heart pumps per minute. They did a tilt test...

Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial Haidong Zhu, JoAnn E. Manson, Nancy R. Cook, Bayu B. Bekele, Li Chen, Kevin J. Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin...

I did my plan of running GSEA on the HEAL2 genes using protein clusters provided by STRING as gene sets, then using the most significant of these clusters to run a second GSEA on the Genebass data for ME/CFS in the BioBank. Nothing came out very significant, the lowest was FDR = 0.220, but maybe...

[...] Herpesviruses and a Faulty Antiviral Response may Contribute to Chronic Multi-Symptom and Multi-System Illnesses in U.S. Military Veterans Brandon Cox, Paula Goolkasian, Irene Mena Palomo, Marshall V. Williams, Sean R. Maloney, Maria Eugenia Ariza [Line breaks added] ABSTRACT Chronic...

Comparison of long COVID, recovered COVID, and non-COVID Post-Acute Infection Syndromes over three years Caleb R. Carr, Nicole L. Gentile, Jeanne Bertolli, Warren Szewczyk, Jin-Mann S. Lin, Elizabeth R. Unger, Quan M. Vu, Nona Sotoodehnia, Annette L. Fitzpatrick [Line breaks added] Background...

I overlaid the plot from this study with the one from the other study. I changed the colors so all the people from this study (ME/CFS + POTS) are green and all the ME/CFS without POTS from the other study are red. Blue is healthy controls from the other study. It looks like the main clusters...

The %CO reduction was lower in the group with a lower %CO reduction? Again some interesting separation: Plot below from their study on people with ME/CFS and normal HR and BP responses, where I was intrigued about why the patients cleanly split into two distinct clusters: those whose...

Update from Dianna. Very moving video. She's doing a lot better, though still far from fully recovered. She describes the the suffering of another person with severe ME/CFS that she's gotten close to, Tobias in Germany. GoFundMe describing Tobias's situation.

Oh yeah, I see that now. Then it seems to me that the separation is to be expected.

Did they group the ME/CFS and LC cohorts together before doing the significance test to pick 3663 DMFs that were differentially methylated compared to HC? If so, I don't immediately see an issue. Separation from the HCs on the plot would be expected, but not between LC and ME/CFS, I think. If...

Merged thread Heart Rate Analysis for ME/CFS St. Denis, Catherine Abstract The article explores Catherine St. Denis's Heart Rate Analysis for ME/CFS, a hybrid work blending medical insight with poetic reflection to illuminate life with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Topics...