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Sure. I wasn't sure if it'd be better to do all variants at once or per gene. Here is all except PTPRD together, but let me know if you want to see them split by gene: Link Plots: PTPRD CSMD3 RAPGEF5 DCC ALDH18A1 GALNT16 UNC79 NCOA3 Edit: I'll just paste all the variants here for easy copying...

At least all the variants for the genes that replicated in the other cohort show "Pass".

Core features and inherent diversity of post-acute infection syndromes Alain Trautmann [Line breaks added] Abstract Post-acute infection syndromes (PAIS), i.e., long-lasting pathologies subsequent to infections that do not properly resolve, have both a common core and a broad diversity of...

I'm not sure I understand why these warnings relate to this study that looked at new genomes. Is it that the warnings indicate that these positions are hard to read accurately? Doesn't that depend on the sequencing tech?

dbSNP has it: rs1553120233

This is also the same cohort as their previous paper that found Complex V insufficiency. (That paper says 51 participants though, so not exactly the same.) [84] Missailidis, D.; Annesley, S.J.; Allan, C.Y.; Sanislav, O.; Lidbury, B.A.; Lewis, D.P.; Fisher, P.R. An Isolated Complex V...

Considering their control group is just individuals from the general population and they didn't attempt to limit to those without ME/CFS, why would they limit it to 323 individuals? Couldn't they have used a few hundred thousand individuals from a database like the UK BioBank to increase...

They have previously described this cohort in another paper: [29] Lidbury, B.A.; Kita, B.; Richardson, A.M.; Lewis, D.P.; Privitera, E.; Hayward, S.; de Kretser, D.; Hedger, M. Rethinking ME/CFS Diagnostic Reference Intervals via Machine Learning, and the Utility of Activin B for Defining...

I haven't been able to make any consistent connections with food. Maybe peanuts cause little bumps on my skin the next day sometimes.

Ha, that's my guess too. We'll find out someday! Though there are a few others around the same p-value of .02, so there might be some other interesting ones too. ¿Si?

Writing a little song about M.E/C.F.S & fibromyalgia. Fade. Invisible Truck Video

Dear ME/CFS by Hallie Walker ME/CFS SONG

Myalgic Encephalomyelitis (ME/CFS) Awareness - This is Me COVER from The Greatest Showman Myalgic Encephalomyelitis (ME/CFS) Awareness - ‘What Was I Made For?'

YouTube has been recommending a bunch of music by people with ME/CFS and I'm surprised by how much of it is really good. So I'm making a thread to compile songs about ME/CFS or music videos that are focused on ME/CFS. Can You Hear Me? | A Song for #MillionsMissing | ME Awareness Still...

I wish they would have tested more nights. REM looks to have mostly recovered by night 7, so far all we know, it was only really low on a single night immediately after running. Total sleep time does seem to still be a little low at night 7 (6.7 hrs) compared to night 21 (8.0 hrs).

I calculated the actual time in each stage using the percentages from Table 2. Minutes of slow wave sleep was modestly higher (11.8%) at night 1 compared to night 7. But minutes of REM was much lower (-63.7%) on night 1 compared to night 7. It looks like the main effect of the marathons was...

That would be my first guess on seeing that data. This similar statement from the text suggests they don't necessarily think REM decreased because it isn't necessary, but that slow wave sleep increased because it is important in recovery: Edit: But the fact that total sleep time decreased...

It seems like they're just inferring that based on the person having less REM after these marathons. Some more from the paper about intense exercise's effect on sleep:

Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart Brief Summary This placebo-controlled, randomized, blinded, two-arm phase II study will test the safety and potential efficacy of the targeted mAb, Sipavibart (formerly...

Impact of extreme physical exercise (28 consecutive marathons) on sleep time and structure, 2025, Buela-Casal et al In this study on a single runner, sleep quality (time asleep, sleep latency, etc) was much worse immediately after running 28 daily marathons and slowly returned to normal over...