Impact of extreme physical exercise (28 consecutive marathons) on sleep time and structure
Gualberto Buela-Casal, Noelia Ruiz-Herrera, Alejandro Guillén-Riquelme, Carlos Zamarrón, Francisco Gude-Sampedro
Objective
It is known that physical exercise influences sleep, however, the effect in...
Affective disorders and chronic inflammatory conditions: Analysis of 1.5 million participants in Our Future Health
Arish Mudra Rakshasa-Loots, Duncan Swiffen, Christina Steyn, Katie F. M. Marwick, Daniel J. Smith
[Line breaks added]
Abstract
Chronic inflammation is associated with psychiatric...
Video on the ME/CFS Research Foundation Youtube channel. It's a really catchy song. The title translates to "What we want". And here is a Claude translation of the auto-generated lyrics:
Google translation of the description:
Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection
Thor Ueland, Rebecca Jane Cox, Annika E. Michelsen, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust...
Impressive looking results.
Only 1 dropout out of 31 in the agomelatine group.
I wonder if it'd be better to individually assign participants to placebo or active, instead of assigning them to "group A" or "group B", because for the group method, if a clinician is able to guess a single...
I think the main question is if the really expensive drugs will still get made. Pharma companies have to spend billions, not only on the drugs that eventually make a profit, but on plenty that never make a dime. If they have to sell these billion dollar drugs at market prices that might not...
I'm working with a beginner's understanding, but I thought we've got memory B cells and long-lived plasma B cells for any particular antigen, and the memory B cells continually create new long-lived cells to replace those that die. So if Dara wiped out the long-lived cells, after some time, the...
PEM definitely affects my diet. I eat more total calories, and eat less variety because I have less energy to prepare foods.
Hopefully, my basic understanding of granger causality is correct, where it would essentially "control" for previous upright time, so it should mitigate confounding from...
I'm still working on my nutrient tracking experiment. Just wanted to outline the direction I'm hoping for it to go.
Data collection consists of two parts:
Nutrients
Using the app Cronometer, I am tracking the weight of every food I eat. Except for very rare exceptions, I only eat foods that...
I guess because the final equation is based on positive differences minus negative differences, so zero differences wouldn't have a place.
But in terms of the theory, my brain is too foggy to follow this right now, but these two webpages give some context...
They used this method described in the paper:
I didn't know what it meant, so I asked ChatGPT to write the Python to calculate this effect size, and using the provided code below I get 0.742.
import pandas as pd
import numpy as np
from scipy.stats import rankdata
# Sample DataFrame with paired...
Oh that is weird. I tried as well using age and height. In dataset 1, there are two participants with age 68 (heights 165 and 167.2), while in dataset 2, there is only one participant with age 68, and they have height 165. There's a participant listed with height 167.2 but their age is 54.
Investigating liminality in the lived experiences of young adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Toller, L
University of Exeter
PhD in Sociology
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Abstract
This study investigates the lived experiences of young adults (aged 18-25) with...
I think the main potential multiple testing issue would be where they looked at the association of CMV with 8 different domains of the SF-36, then only used the most significant for the followup linear regression. If there was barely any pattern of p-values, I'd be more concerned. But 5 out of 8...
The relationship of cytomegalovirus with physical functioning and health-related quality of life in older adults
Frances A. Kirkham, Phu Sabei Shwe, Ekow Mensah & Chakravarthi Rajkumar
Aims/introduction
Cytomegalovirus (CMV) is a highly prevalent virus, known to be associated with...
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