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Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients Toka Elboraay, Mahmoud A. Ebada, Maged Elsayed, Heba Ahmed Aboeldahab, Hazem Mohamed Salamah, Omar Rageh, Mohamed Elmallahy, Hadeer Elsaeed AboElfarh, Lena Said Mansour...

I haven't watched the video, but your summary sounds a lot like the things discussed in a previous video that I summarized in an earlier post. Bolded the parts that relate to a couple of your questions:

I looked at one claim in the response, high urinary creatine as objective evidence of muscle damage in ME/CFS. https://www.s4me.info/threads/urinary-creatine.44616/#post-616907 She cites one unpublished datapoint. Chris Armstrong's team published a paper that seems to show the opposite, but...

Latest preprint 14 June 2025 Integrative Genome-Wide Association Studies of COVID-19 Susceptibility and Hospitalization Reveal Risk Loci for Long COVID Zhongshan Cheng [Line breaks added] Abstract Long COVID presents a significant public health challenge, characterized by over 200 reported...

I just wanted to look at at further evidence for one claim supporting biochemical pathology from the response from Margaret Williams to Jonathan Edwards' hypothesis paper: This paper tested creatine in urine before and after exercise (along with 1400 other metabolites): Urine Metabolomics...

I don't think it's necessary to focus on. She apparently thinks Jonathan is blatantly wrong about that point, so it's understandable to sound a bit more defensive. I'm sure the writers of the "Patients with severe ME/CFS need hope..." paper consider some of the rapid responses they got...

@Jonathan Edwards, I'm not sure if you saw this response from Margaret Williams. She posted it on her website (PDF), and someone also shared it on Phoenix Rising...

The pivotal role of central sensitization in long COVID, fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome Don L. Goldenberg Introduction Long COVID is a condition characterized by persistent unexplained symptoms following COVID-19 infection. These symptoms are not related to...

That's interesting. Is this correspondence on the forum somewhere?

After looking at the paper again, I realized I should have done my GSEA analysis using p-values, not attention scores. I don't fully understand their method for interpreting the model, but p-values are the metric they used for choosing the top 115 that they say are the most important. It didn't...

I'm interested in the "intervention strategies" they would like to see. Specifically wondering if they mean treatment for mental illness.

Postacute Sequelae of COVID-19 Across 12 Major Health Domains and 141 Diseases in Individuals With Mental Illness Among COVID-19 Survivors: A Population-Based Cohort Study in South Korea Jiseung Kang, Jaeyu Park, Yejun Son, Hyeon Jin Kim, Guillaume Fond, Laurent Boyer, Masoud Rahmati, Hayeon...

Executive Function Decline and Its Association With TNF-α in the Later Stages of Post-Acute Sequelae of COVID Aditi Varenya, K. Vijayalakshmi, Mythri Rajeswara Babu [Line breaks added] Abstract Beyond the immediate impact of the COVID-19 pandemic, survivors often grapple with incapacitating...

Employers’ Long Game for Long Covid Scott Conard, Mark Cunningham-Hill, Mohannad Kusti, , Suresh Mukherji, Wayne Rawlins, Stan Schwartz, and Co-authored by members of the National Alliance of Healthcare Purchaser Coalitions’ Medical Director Advisory Council [Line breaks added] In-Brief The...

This seems like a good resource. I read one guide so far, 'Standard deviation versus standard error'. It's a fairly easy to follow explanation of the consequence of studies accidentally using standard error instead of standard deviation in meta-analyses. And it gives three explicit examples of...

T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis [Line breaks added] Abstract Primary sclerosing cholangitis (PSC) is an idiopathic, progressive and incurable liver disease. Here, we aimed for systematic analyses of adaptive immune responses in PSC. By...

Nature: 'How to spot suspicious papers: a sleuthing guide for scientists' An open collection of tips and tools could help researchers and publishers to pick up on problematic research. By Miryam Naddaf ---- 'A group of research-integrity experts has launched a toolkit for researchers that...

Copied from COSIG homepage: --------- Anyone can do post-publication peer review. Anyone can be a steward of the scientific literature. Anyone can do forensic metascience. Anyone can sleuth. However, investigating the integrity of the published scientific literature often requires...

Statistics 101 from OMF Science Wednesdays: ---- Statistics is considered a mathematical way to describe data and test hypotheses. Some of the fundamental components of statistics include p-values, regressions, and confidence intervals. What is a...