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Like others, I find it difficult to be sure. I won’t go into the full history but there was a period of illness either side of ending up in hospital and a few cock ups. After there were ups and downs but I never got better. I’m not sure at what point it became ME. There certainly wasn’t a gap...

Definitely a goal here. However I find it quite funny they are destroying a very profitable business in the process. Ad and web search was there bread and butter but it has been very very much undermined by the proliferation of AI generated content. There may be a future where we are funnelled...

Interesting. Looks like pretty low levels of lots of most of the standard things, sub RDA. But perhaps interesting as it has things like creatine and coenzyme q10 which often seem to pop up being studied independently in more recent studies?

Yes, the idea of what robust data means here is very opaque.

For this prompt I explicitly said the study was flawed and to provide a rebuttal. I get the feeling knowledge of the paper from training data has been picked up here. Given how much on the open web this paper has been discussed it’s probably not great to assume any actual analysis by the LLM...

And here’s the output from my script. Along with a second which was modified to attempt to critique the paper, I didn’t guide it by explicitly telling it the paper was flawed though… —— The PACE trial was a randomized controlled trial designed to assess the effectiveness and safety of four...

I don’t think they’re any good at actual analysis or critical thinking. They tend to echo what is in the paper or common tropes from their training data. We may have some luck if we instruct them to find flaws. But then it’s not really analysis but doing what we ask of them. Does that make...

I think it’s worth experimenting with these tools to see if there’s ways of increasing accessibility to and awareness of long scientific papers for those who cannot or do not want to read them. Whether they’re actually any good at this is of course another question :)

I’ve been experimenting with my own summariser scripts but I haven’t yet hooked them up to use cloud TTS or share these files yet. Here’s example output for these two papers, any feedback to help tailor my prompts very welcome. —— https://www.nature.com/articles/s41467-024-45107-3 This...

I had trying exactly this on my Todo list! From what I’ve heard from others it is extremely good at sounding convincing but can err towards common held arguments or beliefs rather than what is necessarily in the sources. Looks interesting though, especially for high level overviews if you’re...

Interesting, thank you @Jonathan Edwards

Some questions that were going around my head today. What sort of sample size would be needed to replicate this do we think? This has ~1500 people with ME, could a study be done with this (or fewer) people with ME and compared to the healthy controls in the biobank data? Would it be possible...

I heard about this from an article which discusses the paper and the history of Activia. https://arstechnica.com/health/2024/10/popular-gut-probiotic-completely-craps-out-in-randomized-controlled-trial/ Given the prevelence of probiotic and gut microbiome studies I thought it may be of interest

Key Points Question What is the effect of 8 weeks of treatment with at least 4.69 × 109 colony-forming units/d of Bifidobacterium animalis subsp lactis HN019 on complete spontaneous bowel movements (CSBMs) in individuals with constipation? Findings This triple-blindrandomized clinical trial...

I know people who are on lithium for life and it’s my understanding we have no idea why it works for bipolar disorders and there are significant side effects and possibility for complications. Seems a very odd thing to be trying here and a lot of reaching by the paper.

I can feel and share the frustration and anger behind everyone’s comments. You’ve expressed things so well. I pulled out a few quotes which I think sum it up for me. Above all it’s not patients than need monitoring or educating by healthcare professionals but the reverse. Because right now...

Hiccups can definitely be exhilarating for the mouth and decrease sleepiness.

Yes! And ‘strenuous and stressful activity (for you)’ could be things that are that essential.

Fizzy water feels fizzy and you can’t sleep while drinking? Ahhh

A write up of this has been posted by ME Research UK https://www.meresearch.org.uk/trpm3-dysfunction-in-me-cfs-and-the-potential-role-of-low-dose-naltrexone-ldn/