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  1. hotblack

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Haha, I mean, we could… Not using the pipeline I’ve setup though. I’m not sure it’s something I’d want to invest the time in to but… in theory yes we could. Voice cloning has got scarily good.
  2. hotblack

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I’ve now had a first of no doubt many listens. This is great. I really enjoyed it, hope others do and of course most of all hope it gets the right people interested and thinking about the topic. Thanks to the three Jays!
  3. hotblack

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Audio versions are available here https://u.pcloud.link/publink/show?code=kZLPeS5ZBEzVhhjXk8hM18y29vgEGVG6zSvk Any questions, comments or feedback please use this separate thread so we don’t distract from discussion of the paper. Thanks.
  4. hotblack

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I’m sorting an audio version, a few pronunciation questions… “FcγRI” I’m going for “Fc gamma R one” “α1β4 integrin traffic domain”, “Alpha one beta four integrin traffic domain”? “MAIT cells are pronounced “mate” aren’t they? I think most of the others are initialised, things like GDF15, TNF...
  5. hotblack

    Be Nourished - Rachel Jessey

    That jumped out at me too, my understanding is this is a real thing, or rather the application of quantum mechanics to biology is. But like so much of the world of woo, people have taken it and re or misappropriated language and ideas and... *sigh*
  6. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    They’re probably confused at all these hits to their archive page… refreshing looking for new papers. At least we know someone has found the admin password and they’re up and running again!
  7. hotblack

    ME/CFS as a biological information processing problem

    Putting the p value in parsnips?
  8. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Nice work @Sasha :thumbup: I’m just doing names for now.. how about Interferon Mediated T-cell Involved Resource Exhausting Disease Yes, I’m Tired
  9. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Complex pathways you say… Image source and more information here. Or slightly less scarily ‘what is an interferon?’
  10. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Excellent thank you. I can cope with probabilities, greys rather than black and whites. Combinations of complex interactions shifting this or that way. It seems to be how so much in the world works. You’ve often talked about this idea so it makes sense to have it explored more...
  11. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Milligan’s Disease as in ‘I told you I was ill” (Ford) "you'd better be prepared for the jump into hyperspace. It's unpleasantly like being drunk." (Arthur) "What's so unpleasant about being drunk?" (Ford) "Ask a glass of water."
  12. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Or for more fun maybe we can find something that works for Gimlet or Gimli?
  13. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Gamma Receptor, Interferon Mediated, Nociceptor Exciting, Serious Syndrome
  14. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    There does seem to be a good gap in the publishing archive since last Monday (with just one slipping in on Tuesday). Maybe everyone in the office took the week off? https://www.qeios.com/archive?type=article
  15. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Oh well in that case more questions! 1) How would this all fit in with Ryback et al’s findings of increased IGHV3-30 and skewing in the ratio of IgM to IgG BCRs seen in mild/moderate people and not in severe? 2) The basic mechanism seems to be of different cells all doing largely what we’d...
  16. hotblack

    ME/CFS as a biological information processing problem

    It’s well known that pasties cure all and my hypothalamus definitely has a clock which measures how long since I’ve had one. Or maybe it’s just the swede…
  17. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    My first thought was that this could explain why I don’t know my antigen from my elbow… But maybe a nerve needs to know about localised things for other reasons. Perhaps its just a hangover that lots of cells have from earlier cell evolution. Or could it be that it’s useful for a nerve to know...
  18. hotblack

    Intelligent Eye Tracker Integrated with Cylindrical Capacitive Sensors for Chronic Fatigue Assessment, 2025, Li et al

    They only mention ME/CFS in passing in their abstract and conclusion, with the main focus being on fatigue and chronic fatigue.
  19. hotblack

    Intelligent Eye Tracker Integrated with Cylindrical Capacitive Sensors for Chronic Fatigue Assessment, 2025, Li et al

    Intelligent Eye Tracker Integrated with Cylindrical Capacitive Sensors for Chronic Fatigue Assessment Tianyi Li, Seo-Hyun Park, Changwoo Lee, Shawn Kim, Younghoon Kwon, Hojun Kim, Jae-Hyun Chung Abstract Fatigue negatively impacts health, safety, and productivity, yet current monitoring...
  20. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Genecards shows this for expression of FCGR1A https://www.genecards.org/cgi-bin/carddisp.pl?gene=FCGR1A#expression Maybe someone who has a better grip of this can get something useful from the expression atlas? https://www.ebi.ac.uk/gxa/home
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