What type of T cells? By activation you mean they are pumping out cytokines? If so, wouldn’t this have shown up on tests?
If there is abnormal T cell activation, wouldn’t cyclophosphamide or Campath treat this?
Also, what exactly is a hidden compartment?
Thanks.
There are a lot of auto-immune diseases that don’t respond to rituximab like type 1 diabetes and lupus.
Fluge & Mella believe there is an auto-immune component to ME/CFS—from the cyclophosphamide paper
Agree with @Bill—probably not a good idea to subdivide patients with the MECFS syndrome into subgroups based on which symptom is the most prominent or disabling— this is what Guido was trying to do (I think).
Correct. I tried to make this same point on a different thread. Plus they are too busy plus there is no incentive for them to conduct trials/publish results.
https://med.stanford.edu/content/dam/sm/dbds/documents/data-studio/abstract.20201118.pdf
Retrospective data analysis of Abilify plus plans for a randomized clinical trial. 74% of patients reported symptom improvement.
@Jonathan Edwards —your critical thoughts?
Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30354-9/fulltext
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