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The most insulting thing about the whole Opoids crackdown is that prescription rates have declined, yet there is no effect on opioid related deaths in the USA. (prescription rates are /10000) I don't see a cause and effect relationship there. data from...

For me, I had some improvement in the initial years, but it's been a slow but steady decline since then (including new symptoms). I'm not sure (specifically) what really accounts for the improvement, but I'd like to blame age and subsequent infections on the steady decline, even if it isn't true.

There is evidence of an acute (short term) effect on pain through conditioning of endorphins (which are an evolutionarily derived mechanism for us to escape danger when suffering from pain) and a similar effect for acute nausea. There are no other scientific effects. The claim that there is an...

Goals, Page 18. Why is it always Yoga? Of course the young ones these days are woke and will probably reply "No, I don't believe in cultural appropriation" when asked "Have you tried Yoga". ;)

I keep seeing UK people saying "but low deaths" therefore everything is fine, but the UK has had more deaths in the last 3 weeks than Australia has had in total throughout the entire pandemic. And the Australia has 37% of the population of the UK... Of course, even if just 1-2% of COVID cases...

We're having a 7 day lockdown over 3 community cases and guess what? It's worked.

Poor Ramil :(

It seems to be the much larger anti-lockdown "we need to live with the virus" crowd who frequently deny that long-covid is a thing, or think that everyone is going to magically recover 100% within a few months.

While there is no evidence for any sort of generalised increase in autoimmunity risk, you do agree that certain infections can trigger specific acute autoimmune syndromes? Such as Guillain Barre Syndrome and the various autoimmune throbocytopenia and thrombosis with thrombocytopenia syndromes...

The half life of most IgGs is between 7-21 days depending on subtype. While in principle, they can be excreted, most are broken down after being internalised by cells, for example pinocytosis by endothelial cells or receptor mediated internalisation. They can also be degraded by extracellular...

Yes, I was mostly referring to the ones with the valve. The ones without valves don't seal as well and so they leak around the edges due to the pressure when exhaling. (the purpose of the one-way valves on N95 masks is to prevent leakage for the wearer). They aren't fool proof either, though...

Only population based contact tracing studies (where close contacts are tested) can provide answers - and they show true asymptomatic spread is rare: "Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study"...

It turns out having a nasty infection also harms some people's mental health. Who would have guessed?

I'm particularly interested if it helps with your other symptoms...

If your carer is in the house for 5 hours, it is highly likely you would be infected if they started experiencing symptomatic infection. Given the similarity in protection against symptomatic infection compared to transmission, it is clear symptomatic infection mediates most of the effect. We...

If they listened to ME/CFS and post-viral patients back in Jan/Feb 2020, they'd already have conducted prospective population studies and it would not be a mystery.

It is true that patients may not use the word 'fatigue', but that is beside the point. There are also a variety of presentation biases that must be considered. Many ME patients likewise don't complain of "fatigue" unless they have come across medical literature or discussions describing their...

Looking at the high scores (on the site), I think some people are testing algorithms... No way any real person would have that sort of patience.

This is interesting, but requires further replication. In particular, the machine learning sorting processes need to be tested in independent studies. (such as the “PASC Score” defined as S1 = (IFN-γ + IL-2)/CCL4-MIP-1β), where S1 > 0.5 defines a PASC case) The stated specificity/sensitivity of...

The authors claim the presence of spike protein fragments in CD16+ Monocytes is due to continued presence of viral genetic material up to 16 months later. Unfortunately, they don't provide data for each of the patients (for the test of spike protein containing monocytes). They claim: They...