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Yes, and it's probably not even conscious error. People's memories get adjusted by what they want to believe. Their guesses about how much they ate would probably be more erroneous over time, but the 'adjustment' process probably starts immediately.

I strongly disagree. My physically-induced PEM seemed to be due to t-cell activation from muscle damage (consistent 24 hr delay). My PEM did not affect my physical energy production/accessibility. Even my more severe PEM episodes wouldn't have reduced my body's ability to bike 40 km; the...

The records really need to be done immediately. Human memory is too fallible and subject to self-falsification or simple confusion. Maybe I remember eating three pieces of chocolate, but was that yesterday or the day before, or maybe even the week before? The little extras are hard to keep...

That's why we're still waiting for clinical markers: none of our symptoms are clearly defined. We know what they feel like, but communicating that to someone else is problematical. Unfortunately, that leads to 'experts' who come up with theories based on misunderstanding of our symptoms. ME...

It's easier than doing good research. Since the garbage-producers are unlikely to produce useful research even if they tried working hard at it, producing meaningless junk is more rewarding for their careers. Sadly, the system is set up so that they do get rewarded for producing garbage.

Me too! I must have ME! Oh right, I do. I just forgot. :rolleyes: PEM made me want to lie down, but doing so didn't affect my PEM.

If 23/30 mild cases didn't show the virus, then maybe it's not part of ME? My guess is that any immune system activation, from viral infections, tissue damage, or whatever else, will increase the severity of ME symptoms. It's just an extra load on top of ME's symptoms due to the immune system...

Yes, since we don't know the field of view necessary to find ME's abnormalities, we might need studies at different scales. If a brain-wide scan shows abnormalities, they can probably get funding for a higher-resolution, smaller FOV study. Patients are likely to show abnormalities in different...

I like that they're using more than healthy controls. Since I believe ME is neurological (or neuroimmunological), this is the kind of ME research I like to see.

Comparisons with healthy controls are likely to show the differences between 'sick and inactive' people and 'healthy active' people, rather than be ME-specific. This morning I was trying to get an old chainsaw to work. There are three adjustments for the carburetor, and they all have to be set...

I was thinking more about this one. Are there any ME symptoms that absolutely 100% cannot be due to neurological dysfunction? Even muscle dysfunction could probably result from neurological dysfunction, possibly through many steps, but the brain is the master controller for the body. It may...

No, that's not necessary. Some of us, such as myself, had reliable PEM that gave reliable symptoms but didn't cause lengthy crashes. A 40 km bike ride (hilly terrain) would reliably trigger PEM 24 hrs later, which would last a day or so. Surely I'm not the only one who had such reliable PEM...

Any system that offers benefits is going to have people trying to manipulate it for their advantage. The decision makers need to be aware of the latest methods of manipulation. Personally, I think schools should have mandatory classes in manipulation techniques and how to notice when they're...

The shape is all vague and wobbly, because it's likely a set of downstream symptoms that varies with genetics, epigenetics, and various other factors. Those factors affect our individual responses to various other factors too. My priority for PEM would be to find some people with reliable...

Their graphic is just vague speculation. How does that "start to paint a clearer picture"? Until they can find a clear difference in mitochondrial function in all PWME, it's still just a wild guess as to what the mechanism of ME is. Mitochondrial function is probably involved, but cause or...

Nope, you'd be lacking the "unique mixture of negative oxygen ions in this environment". That's an excellent excuse for why this technique--which is so amazingly effective (wild guess, since i haven't read it) in their study--doesn't work for anyone out of the study. ;) I just spent an hour...

Which also means that changes occur in response to disease. Now they need to figure out which changes are causes, and which are effects.

Oh, which mechanisms are those? They list some symptoms, but not any cellular mechanisms. My guess is that they don't have a good grasp of ME, they're just trolling for newsworthy numbers. Another guess: they were hoping to find something amazingly different, such as 80% of PWME having an SNP...

If Tide said that their new detergent was quantum-resonant-enhanced for greater whiteness, I'm sure they could make up some numbers to prove that it works.

Is the Mediterranean diet high-fibre? I never thought it qualified for that. AFAIK, it's the fibre that feeds/supports the bacteria that produce the SCFAs. Hmmm, isn't SCFA production mostly in the colon, while intestinal permeability problems generally occur further upstream? My...