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Humans aren't rational about such things. Religions and superstitions abound, despite no supporting evidence. Humans want to believe in magic solutions for their problems, sometimes desperately so, and will aggressively fight any rational arguments against the magic. I expect there's an...

I'm having trouble deciding what my honest response is, because I've been avoiding certain activities and durations of activities for so long that I'm not aware of my decisions to not do something. Yes, I can be doing an activity just fine, and abruptly I feel worse and know that it's simply...

Unfortunately, yesterday I read a comment in another thread recommending ignoring any Chinese studies involving health and religion/tradition, due to bias. In this case, it sounds far too easy to make the study come up with the results they desire.

It would be pretty hard to convince normal (very busy) people to assign 2 hrs of their days to deep meditation ... just to improve their poo scores. How many people today are you going to convince to going 2 hrs without checking their email/social media? It sounds like a poorly designed and...

That makes me not interested in reading the study. For me, the first 4.5 mg dose provided complete blockage of that pain by the next morning (<12 hrs). If I followed their instructions, it would have taken me at least three, and more likely four weeks to reach a dosage that worked for me...

It's at least possible that people with less grey matter than average are more likely to develop long-covid, or at least report more severe symptoms. I wonder how PWME would compare, and whether the length or severity of ME would affect the volume of grey matter.

Maybe there simply isn't a strong correlation, with ME and Covid, or ME and vaccines. Some people will report worsened ME from either of those, and some will report reduced ME from them.

I had a cytokine assay done, and a few cytokines were elevated or mildly elevated. The immunologist's interpretation was "There's something going on, but it's not a pattern I'm familiar with, so I can't help you." I'm no expert either, but I expect that a few slightly elevated readings are not...

Another factor: easy global communication means that everyone has access to the latest papers. Science is about asking questions, and if you do a quick internet search, you can probably find an answer, and lose the incentive to find the true answer your own way. Sadly, the easily-found answer...

As for the study recently discussed, I'm at least slightly biased to accept it, simply because its findings about LDN match my experiences with regards to dosage, duration, etc. If it claimed that doses under 2 mg were more effective, or that it took several days to show an effect, I'd reject...

The problem is that ME has individual responses. There are plenty of instances where a certain treatment worked well for one individual, made someone else worse, and did nothing for the majority. I found several anecdotes about LDN for ME, agreed that immunosuppression was a valid experiment...

It works well for me.

That would certainly have shown positive results for my trial of LDN. I went from occasional trudges (limited by pain) to multi-hour daily hikes. I did a lot of hiking the winter I first tried it. However, I'm one for whom LDN blocked pain, without any other noticeable effects. I'm not sure...

The problem might be that they realized that they didn't know enough about the brain's systems to model it in a worthwhile way. A few days ago I came across a paper reporting on yet another previously unknown organ (or organ part). It's another layer of the meninges, with extra immune cells...

Right, neither can be clinically measured or even clearly defined. I don't put much weight on studies based on reported pain or fatigue, because those can't be measured reliably.

I did plenty of experimenting with LDN. The effects on my pain were reliable. I forgot doses reasonably frequently, and it was the re-emerging pain that reminded me that I'd forgotten a dose. The pain went away for a few years, and then returned recently, and LDN (several years past its...

I agree that using a fancy word doesn't make it more meaningful. I do believe that ME is an abnormal state that adapts to maintain itself. Imagine that the thermal sensor in a thermostat has changed in a way that changes its response to temperature. You can set the control to 21C, but the...

I like the concept, and hope that it will spread to other researchers. However, a study based on self-reported questionnaires is pretty flimsy. The reported correlations may only be correlations to normal responses of ill people to those questions. My guess is that if they'd included another...

LDN is my second or third best ME treatment (cumin wins the trophy!). It was very effective in blocking my neuropathic pain: muscle aches strongest in my front thigh muscles. One day I trudged about 600 m before giving up that walk, due to the thigh aches. I took my first dose of LDN that...

How do they know that those mice have chronic fatigue? Maybe they just bred a bunch of lazy mice.