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Also from Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany recently: Post-COVID-19 fatigue: A systematic review, 2022, Joli et al Common denominator is Andreas Stengel. Stengel is also associated with the Psychosomatic Medicine Clinic at...

I don't think so. They try slicing and dicing it a number of ways, but always there's too much overlap, even taking into account the likelihood that not all of the people reporting post-Covid symptoms have the same cause.

As Rvallee noted, a sickness response pretty much always had to, and has to originate in the periphery, because that is where the infections start. And it makes sense that at least some of the sickness response happens locally, without the brain getting involved e.g. responses to tissue damage...

I find this explanation so simplistic and all-encompassing as to not be useful. Presumably, I am a genetically susceptible individual, given I have ME/CFS. When I was a teenager, actively growing, I had both EBV (confirmed) and shingles, at the same time. I recovered in a week (the blisters...

I think you are right @rvallee. The finding is just about the specific tissue involved, in mice, responding to the flu. I think it probably isn't paradigm changing, yet at least. It just tells us a lot more about how the sickness response happens and raises more questions, better questions...

Yes, the treatment approach would depend a lot on whether the sickness response was to an actual infection, or just something stuck in the 'on' position. The sickness response does cause real changes in the body, not just the feelings of pain and fatigue. For example, if the itaconate shunt is...

Discussion So the following can reduce the sickness response: * NSAIDS like ibuprofen and EP3 receptor antagonists * Ptger3 gene knockout * ablation of the GABRA1 nasopharyngeal neurons * transection of the glossopharyngeal nerve. The authors discuss the finding that eliminating the sickness...

Experiment 6 - are neurons in other parts of the body that express Gabra-1 contributing to the sickness response (to flu in mice)? No. The authors checked by ablating the NP-9 (Gabra-1 expressing neurons) in the naso-pharangeal area, which would leave any other neurons that express Gabra-1...

Experiments 5 - how are the NP9 neurons affecting disease progression and viral transcript levels? Flu infection produced similar levels of PGE2 in the plasma and in the lungs (BALF - lung wash fluid) in the various types of mice with different neurons knocked out. The authors conclude from...

The work described in this paper is impressive. The authors didn't stop there. Experiments 4 - identifying which particular neuron types are affecting sickness response They sequenced RNA from single nodose, jugular and glossopharyngeal cells, looking for the expression of the Pteger3 gene...

Experiment 3 - What type of peripheral EP3 receptors are causing sickness responses? So, the location of the EP3 receptors that seemed to be accounting for a significant amount of the sickness response in the mice includes the vagus nerve, the nerve to the mouth and throat (glossopharyngeal)...

Experiment 1 - sickness responses to flu infection in mice They infected mice with a flu virus, with the mice going on to exhibit sickness responses. PGE2 levels increased. Also: Ibuprofen and aspirin both reduced PGE2 levels, reduced sickness responses and also increased survival rates from...

The authors note that, as well as generalised responses, there can be site specific responses, such as nausea and diarrhoea in response to gut infections, and coughs in response to respiratory infections. They say that some molecules produced by the body when administered alone to an animal can...

Harvard, Boston. I think this paper highlights a number of areas that could be usefully studied with respect to ME/CFS. To me, it makes sense that a lot of the symptoms we experience are a result of sickness behaviour, maybe a 'dialled-up' response to a mostly latent infection. Of course...

Just wanted to reiterate that. Note, the data is mostly from high and upper middle income countries. So, it turns out all those BPS proponents suggesting widespread anxiety may well have been mistaken.

Hard to know where to place this one, dealing as it does with FND/conversion disorder, but suggesting an autoimmune mechanism for a subgroup. It's a shame there was no control group, with a blinded evaluation of antibodies. (I haven't read the paper yet.) The paper was first posted about on...

https://www.frontiersin.org/articles/10.3389/fneur.2023.1137958/full Open access Team from Kagoshima, Japan Objective: Autoimmune autonomic ganglionopathy (AAG) is a rare disorder characterized by autonomic failure associated with the presence of anti-ganglionic acetylcholine receptor (gAChR)...

Thanks @voner.

Lovely to hear from you, although those cramps and variable heart rate don't sound fun. Given how hard it is to be investigated for this when the symptoms are just pain and fatigue, I'm wondering if it makes sense for people who can afford it to get their genome sequenced, especially those of...

A number of us have had conversations with him in the past; a number of us have donated to his research program. I could try again I guess, but I don't feel very hopeful that he will change his mind about things. I guess he's of the view that patients have told him that something helps, so he's...