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Abstract Raynaud's syndrome is a common dysautonomia where exposure to cold increases the vascular tone of distal arteries causing vasoconstriction and hypoxia particularly in the extremities. Current treatment options are limited and unspecific. Biological mechanisms leading to the phenotype...

HIGHLIGHTS ME/CFS is a disabling chronic disease with a lack of diagnostic tests. Oxygen consumption is a possible biomarker of CFS. O2 consumption allows classifying patients status according to the Weber's classification. A worse Weber's classification infers a worse outcome on the SF-36...

ME/CFS Biobank Austria – Establishment of the First Austrian Biobank for ME/CFS Patient Samples "The first Austrian ME/CFS Biobank has been under construction at the Medical University of Vienna since September 1, 2023, with support from an initial grant provided by the WE&ME Foundation. The...

From the discussion section, "This study also has some limitations. First, we focused on symptoms for each individual at a single timepoint, and thus could not map the change in each participant’s symptoms over time with repeated measures; however, our aim for this study was to provide a...

Exactly, that is the point that Trish is making. Where are they making the claim that the symptoms are the same? Neither or claims that the symptoms are the same.

"David Kingdon is Emeritus Professor of Mental Health Care Delivery at the University of Southampton, UK and formerly psychiatrist and manager with Southern Health NHS Trust. His research interests are in cognitive therapy of severe mental health conditions and mental health service...

8,247 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

Full title: Identifying, synthesising and appraising existing evidence relating to myalgic encephalomyelitis/chronic fatigue syndrome and pregnancy: a mixed-methods systematic review Objectives To identify, synthesise and appraise evidence relating to myalgic encephalomyelitis/chronic fatigue...

'Long colds' are a thing, like Long Covid say experts ""Long colds" can be a thing in the same way that "long Covid" is, with some people experiencing prolonged symptoms after an initial infection, according to a UK study. Common long cold symptoms included a cough, stomach pain and diarrhoea...

Background Long COVID is a well recognised, if heterogeneous, entity. Acute respiratory infections (ARIs) due to other pathogens may cause long-term symptoms, but few studies compare post-acute sequelae between SARS-CoV-2 and other ARIs. We aimed to compare symptom profiles between people with...

Trial By Error: Norwegian Lightning Process Trial Ejects Questioning Participant "The administrators of a controversial study of the Lightning Process currently being conducted in Norway have ejected a participant who expressed critical views about the biopsychosocial approach to ME, according...

From a DecodeME email. "You’re invited to the next DecodeME webinar. This webinar will be a chance to hear updates about the study's progress and have your questions answered. It’s on Thursday 12th October, 1:00pm (BST) on Zoom and Facebook Live. There are only 500 spots to watch the...

Action for ME response, https://www.actionforme.org.uk/news/action-for-me-consultation-response/

Abstract Intrinsic metabolism shapes the immune environment associated with immune suppression and tolerance in settings such as organ transplantation and cancer. However, little is known about the metabolic activities in an immunosuppressive environment. In this study, we employed...

Abstract Black individuals and men are predisposed to an earlier onset and higher prevalence of hypertension, compared with White individuals and women, respectively. Therefore, the influence of race and sex on reactive oxygen species (ROS) production and superoxide dismutase (SOD) activity...

Full title: Cognitive decrements in 1991 Gulf War veterans: associations with Gulf War illness and neurotoxicant exposures in the Boston Biorepository, Recruitment, and Integrative Network (BBRAIN) cohorts Background During deployment, veterans of the 1991 Gulf War (GW) were exposed to multiple...

Is this it? https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(87)90543-5.pdf

Abstract High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge the gap between the genome and diseases. Here we performed association studies of Olink Explore 3072 data generated by the UK Biobank...

Abstract Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers and discover drug targets1,2,3,4. Because previous proteogenomic studies have focused on common variation via genome-wide association studies, the contribution of rare variants...

The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical and biological validations, insights into proteomic disease...