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Now published - link here Preprint Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19 Abstract Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody...

To me Parkinson’s and ME also seem completely different and don’t share notable similarities apart from the natural overlap that many diseases have (obviously the one is a degenerative and deadly codnition whilst the other one isn't). I do think though that the Michael J. Fox Foundation For...

A Phase 3 trial was launched at the end of last year. A study for Sjörgens with Dazodalibep (a non-antibody biologic antagonist of CD40L) was discussed here. This paper discussed that CD40L is usually not expressed on B-cells, but that B-cells infected by EBV do express CD40L. Independently of...

Inhibition of CD40L with Frexalimab in Multiple Sclerosis BACKGROUND The CD40–CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation anti-CD40L monoclonal antibody being...

Could there not be substantial differences to what is meant by unrefreshing sleep in the general context? The study for example suggests that "nonrestorative sleep (NRS)...is associated with greater daytime sleepiness", however I'm not aware that, that would be the case for pwME. From what I've...

Thanks for this effort, a great piece! Let's hope it gets the attention it deserves. I was slightly confused when I if first read "We must seize the grim opportunity Long COVID has presented us to finally untangle the biology behind the devastating chronic illnesses that infections can...

Cohort selection 121 LC patients (selected out of >1,000 subjects at at Long COVID clinics in Leuven, Belgium & Karolinska University Hospital in Stockholm, Sweden) mild to moderate acute infection (non-hospitalised and verified in some way) at least 3 months ago, average age=48 (min-max...

That should be enough funding to now not only run their highly promising study on Red Light Therapy, but even Green Light Therapy and possibly even the whole colour pallet. On a more serious note: I desperately hope the money will be spent on promising research looking at pathomechanisms and...

As far as the OMF released news I’ve read go, Rahim needed a NIH grant. Nothing would have prevented, or prevents, the OMF to fund a study for Rahim and Davis outside of such a grant (if it was obtained), nothing would have prevented the OMF to hire somebody to continue this work in...

Since none of this is actually "news" the most likely scenario is that Davis' team would have long since somehow collaborated or shared their knowledge/data/findings with the team in the UK, especially concerning difficulties they encountered and negative results or there were reasons for this...

He also published multiple papers in the later half of last year https://www.researchgate.net/profile/Rahim-Esfandyarpour/research. If I recall correctly @butter. had some knowledge on the nanoneedle for example not being able to differentiate between ME and MS.

This was posted, suggesting a team-effort: www.twitter.com/user/status/1754586147295019333. However going by other posts it seems these people don't really seem to be too involved: www.twitter.com/user/status/1755145756229378352. I'm thinking that most of them were happy to just say yes to a...

After seemingly slowing down a bit, the pace of signatures seems to have picked up again and 71 000 people have now signed the petition. Quite a tremendous amount for a country with the population size of Netherlands. For what it's worth, it's now under the all-time top 20 petitions on petities.nl.

Cohort selection: n=32 healthy, uninfected controls (HC) n=32 healthy, previously with SARS-COV-2 infected people without persisting symptoms (CC) n=27 Long-Covid patients (PC) I wasn’t able to understand how exactly they ensured the HC group was never infected. It seems they took people from...

The Morten groups take on this paper, exploring a possible role for brain stress: . www.twitter.com/OxMEDiscovery/status/1755491457501143376

The published follow-up data is for 4 years, which is long but possibly not sufficiently long enough from what I've gathered. I believe the unpublished follow-up data will be for 6 years. According to that 18% got back to normal healthy levels in the unblinded Cyclo trial, that is more than for...

We don't and we can't. Virtually everybody has had Covid, this research will never be causal and at best it will detect some correlations that might not be noise. That'll only change if dementia research can ever unlock some more useful markers. So if the findings hold water you will see a...

Temporal Association between COVID-19 Infection and Subsequent New-Onset Dementia in Older Adults: A Systematic Review and Meta-Analysis Abstract Background: The relationship between COVID-19 infection and the increased likelihood of older adults developing new-onset dementia (NOD) remains...

Posted because it seemed "fancy" to a layman like me. It doesn't have any relevance to ME/CFS as far as I can tell (quite the opposite). Ankylosing spondylitis is an inflammatory T cell disease and is majorly driven by genetics. In fact the association to HLA-B27 is so strong that it’s even...

Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis Abstract Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail...