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I was going to disagree with you a bit Rvallee, and suggest exercise is useful for some things, giving the example of Type 2 diabetes. Can't walking programmes tip some people out of type 2 diabetes? Activity, within reason, surely is good. But then I read that point, and realised that just...

That is, higher risks of poor recovery for American Indian and Alaska Native participants

Yeah, we've still got this problem of Long Covid being a whole heap of things. It's not surprising that people who have been through a traumatic hospitalisation will take longer to recover, and might not ever recover their pre-illness health. That's going to really blur identification of risk...

Note the high mean age of the sample. Vaccination prior to infection was also very low (20.5%) - making me think that most of the surveys must have been sent out earlier rather than later. I think that low level of vaccination makes it more likely that the vaccinated people are different to the...

I think this potentially is one of the better studies we have seen - prospective, very large, multiple cohorts. I'm just not sure why the people with reported SARS-CoV-2 infection were such a low percentage (14.2%) of the people who responded to the questionnaire. Given this study was done over...

Worth noting - obesity didn't increase odds, nor a history of 'elevated depressive symptoms'.

It may not be, but I think there are a few things to think about before the idea is chucked away. Here are my example measures again. I don't think some of those heart rates on standing are normal, and the days when standing heart rates were high coincided to some extent with worse ME/CFS...

Yes. But I think it needs to be a cluster of recent cases. With old cases, records are lost, people involved have died and memories have faded... And you aren't just up against a pathogen without a public relations budget and a legal team, your opposition is a wealthy agrichemical company...

That's an interesting thought. There are other factors that might influence base line heart rate - for example, the effort of getting to the clinic for those people disabled by their symptoms might result in a much higher baseline heart rate than normal, making it harder to demonstrate an...

Same. I very much hope this study isn't paid for by the Pycnogenol producers (Horphag Research) with nod and a wink, and a study confirming how wonderful pycnogenol is produced in due course. The study design seems good, so it would probably take either outright fraud or at least some obvious...

Public consultation on New Zealand's system for making complaints about health care. Submissions close 31 Jul 2024 "We are reviewing the Code of Health and Disability Service Consumers’ Rights (the Code) and the Health and Disability Commissioner Act (the Act). You can have your say in our...

Effects of Pycnogenol® in people with post-COVID-19 condition (PYCNOVID): study protocol for a single-center, placebo controlled, quadruple-blind, RCT Protocol for a treatment study, from an institute at Zurich University. They might possibly be a capable partner for other studies and trials...

Looks like a credible organisation, with a commitment to doing and teaching good research methodology. They have a track record in a lot of research related to chronic conditions: https://www.ebpi.uzh.ch/en/translational_research/chronic_conditions_health.html They appear to run an MS...

Swiss study, no declaration of conflicts of interest, which is surprising given the proprietary product being tested. The study plan looks good - lots of blinding and both objective and subjective outcomes. Some of the measures will be interesting to see, even just in the placebo group. I...

I think anyone with a curious outlook and a life-limiting unexplained chronic disease will think about all sorts of possible factors that might have caused them to become unwell. Certainly I have, and some of them I have put in a 'maybe' box and every now and then I try pulling one out (e.g...

From the link above "Associate Professor Erin Howden" The study sounds great, very much needed, and it's not surprising someone with a background in exercise physiology is doing it. AP Howden sounds well qualified to do the study. The fact that ME/CFS is mentioned might mean that they will...

As much as I support the committee's view that the NIH could usefully be reformed, I found this description of what is wrong with RECOVER rather odd. Epidemiological work, setting up registries and so on - that all seems fine to me. Actually, it was leaping into clinical trials of things like...

These authors have been involved in other relevant studies. A prospective 1-year study of postural tachycardia and the relationship to non-postural versus orthostatic symptoms. The Orthostatic Discriminant and Severity Scale (ODSS): an assessment of orthostatic intolerance. Higher postural...

Thanks to @MECFS Skeptic for posting about this paper on another thread.

https://www.autonomicneuroscience.com/article/S1566-0702(18)30298-4/abstract not open access Short Communication - Autonomic Neuroscience The autonomic reflex screen (ARS) has been established as an important clinical tool in the evaluation and diagnosis of autonomic disorders ( Low, 2003 )...