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  1. Jonathan Edwards

    Preprint Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206, 2024, Edwards (Qeios)

    I might add that I was not a member of the NICE Guideline committee. I was invited to give an expert witness report.
  2. Jonathan Edwards

    Preprint Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206, 2024, Edwards (Qeios)

    That is a fairly lengthy series of editorial grouses @Lucibee but in return I can ask for your evidence - which you do not cite. It isn't there. I deliberately published this on a site where positive and negative comments are welcome from everyone (at least I guess with an academic affiliation)...
  3. Jonathan Edwards

    Trial Report Blood Flow To The Head Is Reduced in a Patient With Myalgic Encephalomyelitis With Confirmed Post-Exertional Malaise, 2024, Lee

    Now I am a bit confused. You claimed that it tracked a special left hand vein that tracks brain flow. The problem is that the external carotid (being measured) and the internal carotid (part supply to brain) are branches off the same main trunk (common carotid) so will compete for flow. All...
  4. Jonathan Edwards

    Mirror newspaper article on hyperparathyroidism

    And it seems in Denmark the GP mentality is also actively being promoted by Dr Fink and co (on another thread). Since 2008, all trainee General Practitioners (GPs) in Western Denmark have received basic training in diagnosing FSD and communicating/negotiating the diagnosis with FSD patients...
  5. Jonathan Edwards

    Mirror newspaper article on hyperparathyroidism

    Reading this emphasises to me the failure of the GP system in an age when medicine is complicated and requires specialised expertise and a motivation to be thorough.. When my niece changed from being an ordinary GP to a hospital frontline generalist (a sort of GP in A/E) she commented that...
  6. Jonathan Edwards

    Preprint Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206, 2024, Edwards (Qeios)

    What was intended to be implied was not really a middle ground, more a level playing field I think!! And a referee with a loud whistle.
  7. Jonathan Edwards

    Grip test results and brain imaging in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    This comment from Keller et al puzzles me. My understanding was that feedback control of muscles is all through the somatic nerves going to the dorsal tracts in the spinal cord rather than through vagal afferents. Quoting a theory of infection of the vagus seems a bit random. I am not sure how...
  8. Jonathan Edwards

    Preprint Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206, 2024, Edwards (Qeios)

    I think I meant guideline. I forget but I was under the impression that Charles was suggesting that we need more further guidelines. He certainly gave me that impression when we discussed things earlier in the year. Edit: I find his message confusing. He suggests that I have added some new...
  9. Jonathan Edwards

    Trial Report Blood Flow To The Head Is Reduced in a Patient With Myalgic Encephalomyelitis With Confirmed Post-Exertional Malaise, 2024, Lee

    There are two of them too! It could well be internal carotid but of course that misses the vertebral supply and the proportion of each may change with neck posture. I also wonder if the carotid being muscular and capable of change in calibre it may not be so easy to get a reliable reading just...
  10. Jonathan Edwards

    Trial Report Blood Flow To The Head Is Reduced in a Patient With Myalgic Encephalomyelitis With Confirmed Post-Exertional Malaise, 2024, Lee

    I am not aware of a vein that drains the brain only present on the left side? Pictures on Google seem to confirm my memory that an internal jugular vein comes out through the jugular foramen and passes close to the ear on both sides. Measuring flow rates in IJV would seem a pretty good way to...
  11. Jonathan Edwards

    Infection and chronic disease activate a systemic brain-muscle signaling axis, 2024, Johnson et al

    IL-6 has been a target for treating chronic disease for thirty years now. It would works wonders in some but if infection is present most cytokine blockers are the kiss of death. TNF blockers were developed to teat infection and they made it much much worse. The main drawback worldwide with...
  12. Jonathan Edwards

    Can internal medicine specialists diagnose functional somatic disorders (FSDs)? Training and comparison with FSD specialists 2024 Madsen, Fink et al

    Internal medicine is just the squidgy parts inside the trunk. External medicine includes dermatology, rheumatology, dentistry and no doubt trichology too.
  13. Jonathan Edwards

    When would a GWAS study help disprove the belief that ME/CFS is psychological

    If it is I can't remember where I read it!! It just sounded a good name for a molecule. I am not at liberty to discuss what I read in applications but I have seen some interesting things recently. There are people with good skills and facilities getting involved. In the last six months I have...
  14. Jonathan Edwards

    Financial Outcome Measure

    It's a nice idea, I admit. But the irony is that the 'cost to society' and 'getting people back to work' has only ever in the past been raised in relation to illnesses that people don't really believe in - back pain, depression, and of course ME/CFS. And the solution has always been worse than...
  15. Jonathan Edwards

    Financial Outcome Measure

    I suspect that is the case, although in reality it is the rich people in charge being worried that there won't be enough poor people able to work long hours to make money for them. Nothing to dow with 'cost to society'.
  16. Jonathan Edwards

    When would a GWAS study help disprove the belief that ME/CFS is psychological

    I think it is important to distinguish 'psychological' from 'psychiatric' or indeed 'involving thinking'. Depressive illness is not psychological, nor is schizophrenia, or Alzheimer's or Parkinson's or bipolar disorder. At least it is not psychological in the sense that everyone wants to avoid...
  17. Jonathan Edwards

    Financial Outcome Measure

    But isn't dealing with a glue ear and shortsightedness just a case of treatment working for that person? I am extremely sceptical of this 'cost to society' story. The great majority of people in my part of the world waste their lives moving money around. And money doesn't even exist the total...
  18. Jonathan Edwards

    Preprint Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206, 2024, Edwards (Qeios)

    I might be accused of being ignorant of the biological evidence but I did note that one of the papers quoted was of a study that was an extension of a project Jo Cambridge and I set up with IiME, with five members of my department as authors! (By that time I had decided not to be an author on...
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