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Vitamins K2 and D3 Improve Long COVID, Fungal Translocation, and Inflammation: Randomized Controlled Trial Ornina Atieh, Joviane Daher, Jared C Durieux, Marc Abboud, Danielle Labbato, Jhony Baissary, Ziad Koberssy, Kate Ailstock, Morgan Cummings, Nicholas T Funderburg, Grace A McComsey...

And the Research Roadmap webinar from a year ago had about 30 hours of presentations from dozens(?) of researchers. There must have been some more fleshed out research from some of these groups since then that could have been included. It felt really out of place to include, in what otherwise...

Just noting that there was a fairly large 2022 study that tried to confirm this team's TCA (or TRA, T cell receptor alpha) gene finding, and they found no association. "large Norwegian ME/CFS cohort (409 cases and 810 controls) and data from the UK biobank (2105 cases and 4786 controls)" No...

2016 study, but posting because there was a semi-replication of a gene from an even older GWAS [27]. Both small studies, but just some genes to watch in any future genetic studies. The older study, Smith et al, used Fukuda. It reported the genes significant in both DNA and in mRNA expression...

Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome K A Schlauch, S F Khaiboullina, K L De Meirleir, S Rawat, J Petereit, A A Rizvanov, N Blatt, T Mijatovic, D Kulick, A Palotás, V C Lombardi (Line breaks added)...

Just noting that PubMed now has a note below the abstract that says the 2024 version is an update of the 2019 version. This is still incredible to me. The "update" is that there will be no update: "The Editorial note has been agreed to inform readers that Cochrane is ceasing the production of...

9. Jutras BL, Lochhead RB, Kloos ZA, et al. Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Proc Natl Acad Sci U S A. 2019;116(27):13498–507. Available from: https://doi.org/10.1073/pnas.1904170116. 10. James LM, Carpenter AF, Engdahl BE, et al...

That was my guess. The difference between groups seems too good to be true. I remember in the video by Ron Davis linked above, he said neutrophils are hard to work with because they get activated very easily once out of the body, so maybe the procedure wasn't exactly the same between groups and...

Immune cells mediated the causal relationship between the gut microbiota and anxiety disorders: A Mendelian randomization study Ji-ang Li, Chen-han Zhou, Ze Liu, Hong-bin Guo, Jie-yu Liang, Yi Zhang Highlights A causal relationship between gut microbiota and anxiety disorder (AD) is...

Human Leukocyte Antigen (HLA) at the Root of Persistent Antigens and Long COVID Apostolos P. Georgopoulos, Lisa M. James, Phillip K. Peterson (Line break added) Abstract Here we offer a perspective on recent findings of persistent SARS-CoV-2 antigens in Long COVID through the lens of...

Plain language summary of this protocol from OMF newsletter: ------- "The Serial Pediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME) study explores clinical and biological factors in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among adolescents aged 12–19, a...

I asked Dr. Yonker about that NETosis plot. So the healthy controls were COVID recovered. Interesting...

As far as I can tell, this is only comparing a group of people who had COVID and continue to have brain fog many months later, with a group who got scans before the pandemic. Seems premature to connect the difference in scans to brain fog specifically, but maybe there's some justification in the...

Yes, and the US should make it easier for people on disability to find out about ABLE accounts. I was worried about keeping my savings below $2000 for a long time. Now I've got this account and can save up to something like $250,000. (Varies by state and disability program from $100,000 to...

That's a very stark difference in NETosis shown in Lael Yonker's presentation. Pretty much no overlap. Looking forward to the paper to see what the cohorts are like. Were the healthy controls ever infected? How long after infection for the two groups? If the healthy controls were never infected...

3:03:17 Lael Yonker–Updates for Pediatric Long COVID Main takeaways: Lael Yonker's lab is focused on long COVID in children. She describes earlier research which has shown that children more frequently report a wide variety of symptoms long after COVID infection. Her lab is looking at how...

Autonomic cardiac function in children and adolescents with long COVID: a case-controlled study A B Delogu, C Aliberti, L Birritella, G De Rosa, C De Rose, R Morello, N Cambise, A G Marino, A Belmusto, L Tinti, A Di Renzo, G A Lanza, D Buonsenso Published: 6 March 2024 (Line breaks added)...

Might be just as important to look at where this gene is under-represented. I think in this paper studying chronic lymphocytic leukemia, IGHV3-30 in patients is similar to normal B cells, but IGHV3-30-3 is very under-represented. Geographic patterns and pathogenetic implications of IGHV gene...

So is there like a library of antibody signatures for different pathogens and self-antigens, and the antibodies here didn't match up with anything in the library? Is this the main reason you think it's not likely to be antigen-driven, @Jonathan Edwards?

I'm thinking the IgG/IgM ratio is probably not that important. These are very cheap tests so I would think this would be reported previously if it's a real effect, but I don't see anything from a quick search of the literature. Might just be something like how recently people in this specific...