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What do you think of intrathecal il ten gene therapy? It looks like there are gonna be clinical trials of this soon. There was a clinical trial but it got cancelled. Xt-150 If this works, and fibro/cfs is neuroinflammation, then great we have something in the pipeline...

On another note, anybody know why neuroinflammation conditions are not treated as inflammatory conditions? Eg the neuro degenerative ones https://pubmed.ncbi.nlm.nih.gov/28499701/#:~:text=We argue that a problem,'glia' could be obsolete. Says they've all failed but they haven't done much...

Oh nevermind, mtx activates microglia and astrocytes. Intrathecal steroids are given for cancer too? But, steroids also activate glia...

Uh I had a realisation that there are immune suppressants given intrathecally, for leukemia! Intrathecal methexotrate. And... As with rituximab and lymphoma, some leukemia patients outta have cfs or fms. But no one has reported anything so ig eh. Methexotrate may have anti il one propertied

@Jonathan Edwards also, am I right on this a small trial with a negative outcome is treated as that it is true, but a small trial with a positive outcome is treated as if it's false. Why do we do this? Do we assume that if something is effective it should show through in the small sample?

Hey PEJE. 'This latter model of increasing insular glutamate was recently reverse translated to show that findings of “small fiber neuropathy” could be induced simply by increasing CNS glutamate, as is known to occur in FM' this mean anything? Re sfn talk a while back

I saw a study saying resting during acute phase of virus infection more likely leads to cfs. Does anybody know what I'm looking for? Looking for it bc was a surprise to me. Just like this back pain rest worsens

It is just that they have no concept of how to gather reliable evidence for what they already believe. What does this mean? Sorry im late 5 years I read the transcirpt, so there's 2 schools of thought, the functional disorder one and the we haven't got enough research yet, why does he...

Thank fucking god I have a referral to see this guy good thing I found this. I'm unable to watch videos so I have no idea what happened in the video though

Did pots end up with CFS with that FAABs test showing it was absoluteluseless? Yes I found the thread about it, hard to find gee. That halcyon guy somehow predicted this. Hwo cool https://forums.phoenixrising.me/threads/are-celltrend-tests-reliable-as-an-indication-of-autoimmunity.88076/

Correction, NO is both pro and anti inflammatory

Wait sorry this is an important q so I'll make it a single post, central sensitization is not the same as central pain is it?

On a personal note, I just wNt to add my own ane dote. I have fibro with PEM same as cfs, meaning I can get permanently worse. And. I have been doing so for the past 5 years, though without knowing it bc I used to push myself rest later. Turns out I was slowly getting worse when I thought I was...

Hip Would it even be possible to find evidence for this? Given that glial activation is non specific right? So you would have a hard time ever proving causality? But what if glia activation is actually relevant, but, it's not specific. If you open a dead persons body, they will have glia...

Professor I was wondering your opinion on neuroinflammation, and a quick search of the forums show you're a skeptic. I know you say glia activate for all sorts of reasons. And pretty much any reason. But I'm curious what you think of neuroinflammation in regards to central sensitization, before...

Failed replication in a sample size of like 3? Was it? It was tiny and look at voners comment

I didn't quite think it that far, did Goebel paper provide a way to check levels of antibodies? Also see the MG study, same thing no objective measure but a measure of daily activity https://classic.clinicaltrials.gov/ct2/show/NCT03971422

https://classic.clinicaltrials.gov/ct2/show/NCT05643794?recrs=abdf&type=Intr&cond=Fibromyalgia&draw=3&rank=11 If this trial works, fibro will be autoimmune confirmed for some I think Frcn inhibitor, as goebel described may help. Someone is running a trial, I wonder if he was involved

https://classic.clinicaltrials.gov/ct2/show/NCT05643794?recrs=abdf&type=Intr&cond=Fibromyalgia&draw=3&rank=11 Someone is moving ahead with the theory of autoimmune antibodies for fibromyalgia

Prednisone doesn't cross the bbb though, or at least not much, do cytokines cross into bbb?