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  1. Pyrrhus

    HIV-1 infection alters energy metabolism in the brain:contributions to HIV-associated neurocognitive disorders, 2019, Cotto et al

    I don’t know of any pwHIV who developed ME post-HIV. I vaguely remember Dr. Chia mentioning that of the thousands of ME patients he had seen, about 4-5 of them had HIV. But it’s important to remember that many of the ME diagnostic criteria consider HIV to be an exclusionary criterion. This...
  2. Pyrrhus

    HIV-1 infection alters energy metabolism in the brain:contributions to HIV-associated neurocognitive disorders, 2019, Cotto et al

    The good news is that both factors contributing to HIV-associated Neurocognitive Disorder (HAND) can be mitigated by a careful choice of antiretroviral medication. There are many of these such papers that make it sound like HAND is an inevitable consequence of HIV infection. It is not. I have...
  3. Pyrrhus

    Cases of Acute Flaccid Myelitis in Minnesota and other states

    The CDC has now conceded that Enterovirus D68 can cause Acute Flaccid Paralysis. Although the concession of causality is within the context of a single patient, there may be wider implications. https://www.cdc.gov/mmwr/volumes/68/wr/mm6815a4.htm?s_cid=mm6815a4_w
  4. Pyrrhus

    Exosomes

    There are exosomes that carry up to 40 enteroviruses in a single vesicle. More info: https://forums.phoenixrising.me/threads/viral-exosomes-known-as-‘stealth-spheres’.75937/
  5. Pyrrhus

    MEPedia is offline

    MEpedia is currently implementing much-needed improvements that will require intermittent downtime to install upgrades. These intermittent outages will continue for a couple of days. One of the major goals of these improvements is to make the process of contributing to MEpedia easier for...
  6. Pyrrhus

    MEpedia Down

    Just to clarify, the problem is not with MEpedia, it is with the ISP. All MEpedia can do is wait for the ISP to fix the problem.
  7. Pyrrhus

    Cases of Acute Flaccid Myelitis in Minnesota and other states

    And now NIAID has weighed in, with a somewhat more urgent outlook than the CDC’s: https://mbio.asm.org/content/10/2/e00521-19 Ten years ago people warned that Enterovirus 71 would be the “poliovirus of the 21st century”: https://www.tandfonline.com/doi/pdf/10.1080/10158782.2009.11441350...
  8. Pyrrhus

    Minister targets anti-vaccination websites - BBC March 2019

    Quite true. But the vaccines could have been major contributing factors. Unfortunately, we may never be able to untangle the contributing factors to assign a specific etiology. Also consider those soldiers that were exposed to vaccines, but not to the organophosphates...
  9. Pyrrhus

    Minister targets anti-vaccination websites - BBC March 2019

    You may be interested in the following paper: https://www.ncbi.nlm.nih.gov/pubmed/24914115 The paper only considers one particular combination vaccine, but it found a doubled risk of seizures from the combination vaccine compared to separate vaccines.
  10. Pyrrhus

    Cases of Acute Flaccid Myelitis in Minnesota and other states

    Update from the CDC: https://www.cdc.gov/mmwr/volumes/68/wr/mm6812a1.htm?s_cid=mm6812a1_w Good to hear the CDC is trying active, prospective, surveillance. Active, prospective, surveillance is the only real surveillance. CDC’s passive surveillance approach is extremely limited in its...
  11. Pyrrhus

    Frontiers review - Chronotropic incompetence an overlooked determinant of symptoms and activity limitation in ME/CFS (prov. 2019) Davenport et al

    Thank you for the clarification. It sounds like one might have to posit anti-adrenergic antibodies, not some central mechanism, if one wanted to posit failure of arteriole dilation then. (Assuming it’s consistent with observations on blood pressure during exertion.) I’m curious- you haven’t...
  12. Pyrrhus

    Frontiers review - Chronotropic incompetence an overlooked determinant of symptoms and activity limitation in ME/CFS (prov. 2019) Davenport et al

    Thank you so much, @Snow Leopard , for the intriguing crash course in exercise physiology. I still have a lot to learn about this subject. Your hypothesis makes perfect sense. And I see why an EMG would be able to confirm or refute your hypothesis. But I wouldn’t say that your hypothesis is...
  13. Pyrrhus

    Frontiers review - Chronotropic incompetence an overlooked determinant of symptoms and activity limitation in ME/CFS (prov. 2019) Davenport et al

    I'm very curious- what could be determined if EMG signalling is measured? On which nerve(s) would the EMG be conducted? What would an increased latency or reduced rate of HR rise indicate? If you’ve addressed this elsewhere, just point me in the right direction... ETA: Ok, I have gone back...
  14. Pyrrhus

    Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing PEM following cardiopulmonary exercise testing, 2019, Chiu et al

    Not at all. Although people have talked about viruses ad nauseum for decades, there has been very little true high-quality research to actually look for viruses. This paper appears to be high-quality research, but is just the beginning of the true hunt for viruses. So we’ve looked in the...
  15. Pyrrhus

    Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing PEM following cardiopulmonary exercise testing, 2019, Chiu et al

    It’s so good to see Stevens, Van Ness, and Snell pair up with someone like Charles Chiu. At first glance, the study design seems excellent. They tested before, during, and after PEM induced by the two-day CPET. Canadian criteria, all female. N=14. Used the technique called RNA-seq. Only...
  16. Pyrrhus

    false assumptions about viral infections

    This is not exactly what you’re talking about, but it is possible for a viral quasispecies to move from one cell to another. In the case of enteroviruses, this phenomenon has recently been named “stealth spheres”. A “stealth sphere” is a single membraned extra-cellular vesicle enclosing...
  17. Pyrrhus

    false assumptions about viral infections

    Very interesting, thanks for sharing. There is a related phenomenon, researched by Raul Andino, of ”viral quasi-species”. In this scenario you have many defective versions of a virus in a single cell. Although each individual defective virus is missing a part needed for infectious pathology...
  18. Pyrrhus

    ME/CFS International Research Symposium, March 2019, Australia

    For the record, this is not a generally accepted assumption in the field of virology. In fact, there are numerous examples of persistent viral infections that leave no trace of their existence in the blood. Ron Davis’s claim is an extraordinary claim, and extraordinary claims require...
  19. Pyrrhus

    Skin crawling/formication

    The sensation of insects crawling on your skin, when there are actually no insects, is called “formication”. It is a neurological symptom, but very little is known about it.
  20. Pyrrhus

    Dr Jonathan Kerr

    For what it’s worth, Dr. Chia does not use interferon. He tried it in some patients many years ago, but soon abandoned the idea.
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