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Hard to take anything useful from this paper... Seems like all of Jason's studies are now based on that distinction between moderate ME/CFS and severe ME/CFS. But the latter is not actually severe ME/CFS, just patients that meet more than one case definition for ME/CFS. They then conclude...

Think it's mentioned in the text, not in a table.

Been a while since I read this paper but think this is found in the test by group interaction of their ANOVA modelling.

Looks like they failed to replicate the 2-day CPET results, although look forward to seeing the actual data. The most replicated finding was workload at the ventilatory threshold which they don't report in this abstract.

An older study that I hadn't seen discussed much. It uses insurance data of the company Medical Sickness Group. Found 133 CFS cases and compared them to MS patients and non-claimant controls. They could look at a median of 10 years before the claim of CFS. Results showed that ME/CFS patients in...

Link: https://pubmed.ncbi.nlm.nih.gov/9507441/

Don't remember, this was back in 2021. Probably no reason, just a rejection.

Trial data suggest that Coenzyme Q10 plus NADH supplementation is not an effective treatment for patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Castro-Marrero and colleagues conducted a randomized controlled trial on 207 patients with myalgic encephalomyelitis/chronic...

Wrote a critical letter to the journal to highlight the problems but it was rejected.

The German ME/CFS Research Foundation also has registry where they list ME/CFS projects since 2019. It initially focused on Germany only but has expanded to a couple of other countries such as The Netherlands. Research projects – ME/CFS Research Registry

I doubt that AI could do this, what I have seen is mostly people using existing PubMed tags or things mentioned in the abstract. With a team it should be doable to screen all ME/CFS papers on PubMed: there are approximately 7700 at the moment. Many are short commentaries or letters. I (and many...

To give an example, it allows you to filter on symptoms such as post-exertional malaise. It would be quite useful to quickly get an overview of studies that focus on PEM as its main topic. Unfortunately, this website probably uses mentions of 'post-exertional malaise' in the abstract. This...

The website looks impressive but it seems like it's mostly AI summaries and AI evidence ratings of ME/CFS studies. That can give impressive looking overviews and graphs but if nobody is doing the hard work of checking and evaluating results, then its quite the opposite of useful.

Looks like there was no control group. I also thought they already published similar data in this paper: Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome - PubMed

Looks like fluvoxamine is a serotonin reuptake Inhibitor but that it's a bit different than other antidepressants because of its high affinity for sigma-1 receptors. Would be interesting to compare fluvoxamine to another SSRI and a placebo to see if it beats both.

Yes or a check to see if dropouts differed in their baseline measurements. They don't give much info on them. They did try to check for this possibility by looking at an interaction between fatigue improvement and baseline anxiety/depression measured with the EQ-5D-5L. They found no significant...

This reserach group of John Imboden at John Hopkins had published a similar study on patients with chronic (> 2 years) symptoms following brucellosis. Here the psychological measurements were taken after the patients were already ill and the sample size was even smaller (n = 8). It included a...

Here's my own summary: in 1957 600 people filled in two questionnaires: the Minnesota Multiphasic Personality Inventory (MMPI) and the Cornell Medical Index Health Questionnaire (CMI). Asian influenza broke out and 27 out of 600 people got ill. They divided those 27 in a group of 14 that...

An old study that is frequently cited in the psychosomatic literature on ME/CFS. Suspect it influenced a lot of people. It concluded that personality and emotional factors influence recovery from Asian flu in the 1950s. Convalescence from influenza. A study of the psychological and clinical...

The paper writes: So the conclusion seems to be that prior-day symptoms are useful predictors but that biometric features add almost no additional information to that.