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Yes I think a replication of DecodeME in Germany with a possible whole-genome-sequencing follow-up like sequenceME would make a lot of sense. It was just relatively cheap: around 3.2 million pound (compare that to the 1000 million that has been spent on LC research and what came out of that)...

Yes this looks like what is needed: https://www.dzne.de/en/research/brain-bank/ A well-funded ME/CFS program within DZNE brain bank would make a lot of sense. You need an experienced institute to organize all the consent forms and collect the brain samples in time.

The genetic findings of DecodeME strongly pointed towards the brain and the autopsies from the Netherlands have reported notable findings. So I think a priority should be to collect brain tissue from ME/CFS patients.

Yes

Yeah I think that's quite possible, it has the second largest probability (PIP) in SUSIE. Below are the 12 SNPs that carry 85% of the probability. The two most likely candidates are those at the top because (1) they have the largest probability and (2) they are the only ones that are...

Yeah, I also think this is where the action is. I the graph above, I finemapped this locus using SUSIE and LD data from UK biobank, similar to what Trafalmadorian did here. In summary, this uses the correlation among SNPs in the big UK biobank cohort to estimate where the signal is coming...

Hi Isabelle, this is one of the latest updates: Persbericht: patiëntenverenigingen kritisch over nieuw RIZIV-zorgpad - 12ME The Newspaper The Morgen also reported about the plans in August: Waarom longcovidpatiënten nog altijd te horen krijgen: ‘Ik geloof niet in long covid, hier is het nummer...

It's curious how different the results are in the total group and severe subgroup. Because the subgroup contained 78% of the total sample, there must be big differences with the 22% that were left out in the subgroup analysis. It's unfortunate that we're not exactly clear what subgroup this is...

I was wondering about this too because the goal is to compare ME/CFS cases agains the rest of the population, not necessarily those with good or excellent health. So it could have caused an additional selection bias. I assume it was to make sure that none of the controls accidentally had ME/CFS...

I was thinking about (FUMA-defined independent) regions because many of those 287 variants were highly correlated and represented the same signal. It seems that there were 12 independent loci in this discovery cohort reaching the significance threshold, while there were only 6 in the main...

Interesting analysis, thanks to the authors! I find it strange that the analysis of 1,268 ME/CFS cases found more significant hits (SNPS with p < 5 * 10^-8) than DecodeME with 15,579 cases (and double the amount of controls). The effective sample size was only around 5000. This doesn't fit with...

Looks interesting. I wanted to calculate the genetic correlation with DecodeME but it looks like the summary data isn't available? https://kp4cd.org/node/1692

Yes, it also feels like a pissing contest between OpenAI and Anthropic. Solving scientific problems as fast as possible to show investors how advanced their model is. At least they're throwing talent and money at things that might actually be useful - probably better than creating credit...

@Jonathan Edwards would be interested in hearing your views about this, especially regarding whether AI has true intelligence, understanding, and insight. Also, with your expertise in research on consciousness, do you think AI models already have consciousness, that they will get it in the...

I think most of the world doesn't see this yet, because you have to have one foot inside programming or math to really understand how powerful AI is at the moment. Most people's experience of AI is asking it a question instead of googling it - so a single agent, on a free version, not the...

Not so sure about this because, in essence, it comes down to how much one can extrapolate from the data we collect. How many more scientific rules and principles can an AI distill from those than us? I guess that it's likely a lot. Perhaps the AI will be able to predict those novel...

I thought that Dibble (T-cell repertoires) and Ryback (B-cell repertoires) already did this, but without clear results.

Thanks, although I already had the impression that DCC is one of those long genes that shows up in a lot of places.

I'm not so sure, suspect we're almost at the point where AI (the top models like Claude Fable or GPT-6-Astra) is better and faster at coding than almost all human coders. I don't have a coding background though, so perhaps others can provide more insight. It seems to have already have made an...

Feel free to share more insight from the mathematics community because it feels like insight/warning about what's going to happen in many other fields. The coding community is similarly affected but it has many people wanting to hype AI because of commercial interests, so I feel like the...