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Been wearing a Garmin with HRV monitoring for a couple of years. My HRV reliably drops when I've had a stressful day or consume alcohol. Haven't noticed any correlation to crashes. N=1 though.

Not sure if they have controlled for baseline activity level. Sedentary folks have reduced respiratory muscle strength. I would have expected the findings to be based around the small fiber neuropathy/endothelia dysfunction/mitochondria problems/pre-load cardiac shortfall issues that have...

Pneumonia is my most likely cause for this disorder. No surprise at this finding.

I found this to be a really good article with lots of good information.

Do we know if lactate is only correlated with or actually causes PEM?

Here is a link to the article. The Effects of a Carbohydrate Hydrogel System for the Delivery of Bicarbonate Mini-Tablets on Acid–Base Buffering and Gastrointestinal Symptoms in Resting Well-trained Male Cyclists | Sports Medicine - Open | Full Text (springeropen.com) Sodium bicarbonate...

Lewis A. Gough and S. Andy Sparks are authors. Sports Medicine - Open Abstract Background A new commercially available sodium bicarbonate (SB) supplement claims to limit gastrointestinal (GI) discomfort and increase extracellular buffering capacity. To date, no available data exists to...

Citrulene is a dietary supplement that has also been shown to improve vessel dilation. There are also prescription medications such as erectile dysfunction drugs that help vascular dilation. My N=1 experiment with citrulene and beet root extract is that they may have improved vessel dilation...

This looks like a reasonable mechanistic explanation for exertional intolerance. Orthostatic hypotension as well. Not sure how it would explain PEM unless that is through the sodium and calcium overload.

This fits my experience. I try to be a competitive masters swimmer despite my mild ME/CFS. I can maximally sprint 25 yards in about 12 to 14 seconds (nationally competitive times for my age group) with no limitations except catching my breath afterwards. I can, but struggle to sprint 50...

I have mild ME/CFS with dysautonomia symptoms including OH. I have tried supplementing with Citrulene and beet root extract, both are vasodialators. What you describe is my N=1 set of symptoms. I get increased OH from the supplements. I also understand that a primary drug treatment for OH is...

One of the authors of this study just posted on Twitter: 2 years ago we published this study suggesting significant mitochondrial dysfunction in Long-Covid patients. The idea was so crazy that we weren't able to include "mitochondrial dysfunction" in the article title. Instead, we had to used...

Interesting. Thank you for linking that research study.

The title of this thread made me think of vaso-dilators. There is literature in the sports/athletic community that says that certain supplements can lead to vaso-dilation and that helps moderate some exercise-induced fatigue. Namely beet root juice and Citrulene. In athletes, the...

I have mild symptoms overall. I have been on fludrocortisone for many years and it definitely helps my OH. I usually don't have to worry about standing up too fast unless I'm in a PEM phase or in a very hot environment.