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    Unwilling or unable? Interpreting effort task performance in myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Kirvin-Quamme et al

    When I first began working on this project, I assumed the process would be straightforward. There were so many misrepresentations of the data and clear examples of questionable research practices that I thought simply pointing them out would make the need for retraction self-evident. But my...
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    Unwilling or unable? Interpreting effort task performance in myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Kirvin-Quamme et al

    Thank you all so much for the kind words. It truly makes all the hard work feel worth it. Echoing Karen, I wish I had the bandwidth to reply to everyone individually, but I’ve been pretty short on spoons lately. @ME/CFS Skeptic We were definitely pretty disappointed that Nature Comms refused to...
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    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    Hi everyone, I'm cross posting an update from the EEfRT offshoot thread— I’m very excited to share that our critique of Walitt et al.’s effort preference claims was finally published today! The article is titled Unwilling or unable? Interpreting effort task performance in myalgic...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Hi everyone, it’s been some time since I last posted, but I’m very excited to share that our critique of Walitt et al.’s effort preference claims was finally published today! The article is titled Unwilling or unable? Interpreting effort task performance in myalgic encephalomyelitis/chronic...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Matters Arising Manuscript Update: Finalizing everything took a bit longer than anticipated, but I’m pleased to share that the manuscript was officially submitted to the journal today! I’ll keep you all updated once we receive a decision, but since reviews typically take some time, no news...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    We are hoping it will be accepted by Nature Communications as a Matters Arising article and that Walitt and Nath will also publish a formal reply in the journal. If the Nature Communications editor rejects the letter then I think we will publish it on a preprint server so that it can be cited...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Quick update about the letter: We sent it to Walitt and Nath yesterday and asked them to have their response back within two weeks. Once they've responded we will discuss if any revisions are needed in light of their response and then submit the manuscript to Nature Communications. So it will be...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    It's still in the works. I crashed and had to take a break from working on it for a bit. The current plan is for me to have the next draft of revisions ready for the co-authors to review in mid to late June. So hopefully looking at sending it to the NIH researchers in July and submission a few...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Could you say a bit more about what you mean by using difference in motivation effect? I don't think I've heard anyone ask about hypothesis testing versus data exploration and the use of p-values explicitly. I would love to see them confronted about this. In the call yesterday, Walitt openly...
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    2024: NIH National Institutes of Health - ME/CFS Symposium on Intramural study - 2 May

    My guess is that Walitt just said what he said because people have been writing in saying that their framing of effort preference is offensive because it implies that people are choosing to be disabled. He's trying to spin it so he can head off that criticism and make it look like he was...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    For those who weren't able to tune in, they did answer (shortened) versions of my two questions. Here are quotes of what the moderator asked and the answers given. My original question 1: What the moderator asked: Nicholas Madian's Answer: As a reminder, here is the exact quote from the...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    I think this is framed well @Evergreen, would you be open to submitting it or having someone else from the thread submit it? I think this version does a good job of highlighting the logical issues without needing to rely on Treadway's perspective. The email for submitting questions is...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    I decided to submit two questions ahead of time. Here is what I submitted. I think it's unlikely that they'll include them but it doesn't hurt to dream. You reported in the article that the PI-ME/CFS participants had significantly lower successful completion rates for the EEfRT's hard trials...
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    Grip test results and brain imaging in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    The EEfRT data and grip data are both shared on the MAP ME/CFS website. Grip data is in the "Post-Infectious MECFS at the NIH: Body Composition, Exercise, and Bioenergetics" data set and EEfRT is in the "Post-Infectious MECFS at the NIH: Neurophysiology" data set. The EEfRT data there is only...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    I don't think there is, as far as I know. It would probably be nice to have it all in one place, but I doubt the journal would publish it. It could be posted as a comment on the article or self published on a preprint server. I'm not sure whether or not to ask about it. Also not sure if...
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    Grip test results and brain imaging in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    For the full sample, time to failure correlates with hard task completion rate for both the dominant and non-dominant hand, but the latter should be more relevant since that's the hand used for the hard task. Caveat is that Kendall's tau is barely not significant for non-dominant. Both dominant...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    I'm sorry I haven't replied to your messages @JoClaire, working on the draft has been taking all of my spoons and then some. I really appreciate all of the contributions you've been making. Let me know if there are any open questions that I missed. I think it's really concerning that they...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    I think we finally have our smoking gun. Our argument has been weakened so far by lack of statistical evidence that ability to complete the hard trials is related to Proportion of Hard-Task Choices (PHTC) aka "effort preference". When I tested for this previously, I used a pearson correlation...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    I'm really impressed with all of your work on this @Dakota15, thank you for everything you are doing I think it could be really fruitful. This strikes me as a smoke screen. This would be true of any PI on any large study, they are never the ones that administer the task or do the majority of the...
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    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Sounds good! I'll send the link as a private message. I had missed your message about Ohmann's response but I just went back and read it. That's disappointing, I don't get how you could see the discrepancy in hard trial ability and not conclude that this is invalid. I am still slightly...
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