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A better title would be: Advancing understanding of quantum walk-based network analysis through playing around with long covid.

Not sure about the retrospective patient analysis nor the EBV stuff, but the blood microscopy looks like a good contribution to step-by-step science, they clearly describe what they did and what they saw. Allowing anyone else to see if they can replicate. Having these aggregates floating...

Strengths: big journal, good university, fascinating and possibly useful finding about role of peripheral neurons in controlling mitochondial metabolism. there's a clinical trial going on in mecfs on a guanyl cyclase stimulator, vericiguat. Weaknesses: research was done on little wee worms.

Proc Natl Acad Sci U S A 2026 Mar 10;123(10):e2525619123. doi: 10.1073/pnas.2525619123. Epub 2026 Mar 4. Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress Rebecca Cornell , Ava Handley, Roger...

1. this thread of tweets has the precise flavour of chatgpt output. A beautifully written summary but without much discrimination applied of whether what they are summarising may or may not be true. 2. The supposed decrease in NK cells is based on a pretty small dataset, good on them for...

Transnosological is a new and interesting word for me. It aparently refers to focusing on symptoms even if they cross disease boundaries. A transnosological approach to fatigue would be a good example. it's part of everything, be great to get more ideas why.

There's a cynical part of me that thinks we ought to focus on what we have in common because funding for US military' veterans issues, while it may be imperfect, is a significantly larger pot of money than funding for diseases that mostly strike women.

So EDS is linked to POTS, EDS shows reduced platelet aggregation, but Iwasaki and company were proposing increased platelet aggregation in ME/CFS? It doesn't make sense yet, but not in a way that I'm dismissive of: I'm certainly paying attention. This measurement they are making - integrin...

At the risk of getting things off-thread I should correct myself and say I know of one hopeful example of untargeted work leading to targeted work, which is this 2011 gene study that surfaced wasf3 as the top candidate and got no attention at the time: https://pubmed.ncbi.nlm.nih.gov/21584188/...

Is there evidence of untargeted metabolomics or proteomics revealing answers in other diseases? I grow less and less excited by -omics studies that have to bundle together a panel of 15 molecules just to get an area under the curve of like .83. And then gesture very broadly in the direction of...

If you don't want to be wrestling wiggly worms back into a can and fighting infuriated nomenclaturists at every turn, you need to choose something with near-zero-specificity and no emotional cadence. A real eye-glazer. Something like: related acquired illness grouping.

This is 99% likely to be complete nonsense. 99.9% actually. Not only do they claim to have discovered a whole new thing: telomere transfer - they claim it causes rejuvenation of whole organisms. They claim to have almost doubled the lifespan of mice, by intervening when the mice were already...

Abstract The role of the immune system in regulating organismal lifespan remains poorly understood. Here, we show that CD4⁺ T cells release “telomere Rivers” into circulation after acquiring telomeres from antigen-presenting cells (APCs). River formation requires fatty acid oxidation at the T...

Has the scale and feel of a PhD thesis, but as a proof-of-concept it is intriguing. One day perhaps we can have a little thing like a covid test that spit goes in and which provides some objective measure of PEM.

Weird study. They accidentally had a 70% recovery rate in the placebo group. Notably the symptom that improved most in all groups was PEM, to which they gave very high weight in assessing overall illness. Very hard to know if they are seeing true recovery or symptom fluctuation. Also, At the...

This blogpost is not unhelpful, it's a person with some interest in the disease kicking the tires of some ideas, large and small. This is part of the intellectual environment, alongside forums like this, and formal research. It contains a few things. One is the idea of "setpoints" which seems...

@mariovitali I know you love post translation modifications, so here's a new one for you, pyruvylation.

Media coverage makes official channels work properly! Not long ago I found some asbestos in a children's playground. It led to a national media outrage and a lot of other playgrounds being shut when asbestos was found in those playgrounds too. Some systemic change happened. During the whole...

1. Perhaps what's most useful here is that they use reads of the ebv genome found in the UK Biobank, just as a byproduct of sampling blood to get the human genome. It proves to be a reasonable measure of ebv viral load. This could be a good measure to include in a future ME/CFS biobank study...

This paper is now officially out on PubMed and online. Took them 7 months but they got it into Nature. some terminology has changed from the above and they dropped reference to the mendelian randomisation from the abstract. Apparently lots of diseases are implicated as being associated with...