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I've shared this paper before, but one possible reason for changes in glycosylation is endoplasmic reticulum stress. ER stress causes a homeostatic response called the 'unfolded protein response' which has many effects, including, the paper says, changing the way glycans get added to proteins...

I encountered something like this in real life when a doctor tried to insist I should not nap. All the research, he argued, showed that people who don't nap feel less tired. I told him I would not be following that advice and a look of genuine distress crossed his face.

https://www.owlposting.com/p/mapping-the-off-target-effects-of This is great, an interesting essay on some very useful work. summary: Most pharma companies don't really care too much about discovering every off-target effect of whatever drug they are pushing through clinical trials. Why...

This chart should be data on the same cohort. A large majority of those on contraception scored over 100 and therefore must be in the ME group. If I'm reading this right, almost everyone they got in their study who was on contraception also had ME. (plenty of people with ME and not on...

If we were properly treated I don't think continuing to distrust physios would be a rational approach! They've always been good at treating people who are healthy just unfit. Problem is that's not us. In your scneario it would be though. That said I've had remissions and it's just not a hard...

Wust's colleagues have some preliminary data with some pretty striking separation between patients and controls. . Very hopeful line of research. Pleased it is happening in Europe rather than the USA given funding. With a bit of luck, money will continue to flow

the great thing about the POTS researchers, and the patients, and this company, and hopefully a few competitors, is they will chug along anyway and we can find out if your view was right.

Just thought this was an interesting one, you never see the medical establishment publish anything against exercise, but this study looks quite well-powered to draw the (limited) conclusions it draws..

Brain 2025 Jun 18: doi: 10.1093/brain/awaf235. Online ahead of print. Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis David O'Brien et al, University of Sheffield...

I think they are trying to make the arbitrary heart rate definition redundant! There's wide awareness that cerebral blood flow matters, it's just been a nightmare to measure via transcranial doppler. The HR change is thought to be secondary to the reduced flow, compensatory. The reduced flow is...

The more recent video that I shared includes a person with no dysautonomia diagnosis using the device and that person also shows blood flow to the head falling on standing. So the question of specifically what is different between POTS and non-POTS in terms of the read-out is not yet clear to...

I find the term unrefreshing completely unscientific and ambiguous. If I don't understand a word I try to break it down. Unrefreshing must be the opposite of refreshing. Refresh must be the process being described. What does that mean for a person? Should I feel "fresh"? Again? What would that...

This is a detailed study on the proteomics of acute and sustained exercise in the healthy, it is paywalled but definitely the sort of paper that can help establish norms against which we can measure PwME. It also hints at a supplement that I'm about to check and see if we have any forum posts...

Here's another good chart from the thesis: Figure 21| ζ-potential (mV) of PBMCs versus time during incubation in hyperosmotic NaCl medium in |A| severe ME/CFS diagnosis donors (unchallenged black circles, NaCl blue triangles; n = 8) |C| mild/moderate ME/CFS diagnosis (unchallenged black...

There's another new video here from Lumia featuring POTS researcher Satish Raj. it's a bit scrappy, this video, they were tryig to integrate an experiment and an interview and it suffers from not seeming very smooth and professional. but nevertheless it is interesting. And in this thread a...

I consider myself mild and I'm amazingly fit for a person with ME; I'm more open to exercise's benefits than most, especially recumbent exercise. But .... 50 sit-ups and a minute of plank is the warm up!?!?! I just don't think you could find 12 overweight people who can do 200 situps in their...

Here's an older paper that I just found that reveals an interesting fact about UPR. It doesn't just work in the affected cell, it can transmit to other cells, which then begin the same UPR process. https://pmc.ncbi.nlm.nih.gov/articles/PMC11475223/ And guess what they think the mediators are...

I fear that maybe mendelian randomisation studies suck because it is cheap to do. You don't need any samples or pipettes, microscopes or a lab. You need nothing more than a database and a copy of some free stats software. Barriers to entry are low and so, even though the technique can be...

The r^2 on these looks good but the actual separation on the vertical axis ... isn't there. So the link with PEM is one to be wary of. I'm excited by ER stress and the link with Hwang's work but this is preliminary in my view. That said, EVs could be a really good place to hunt for UPR...

hmmm. Affinity for breakfast is a novel concept in medical literature. This is the sort of groundbreaking research we need. We should petition to get the name of this illness changed to breakfast affinity syndrome. [SARCASM TAG INCLUDED HERE FOR FEAR OF MISUNDERSTANDING !!]