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It depends on how large the effect is and how large the effect of other factors is, and how many false positives (multiple PWME who share a gene, but due to a non-genetic common factor). If the study requires a billion PWME to overcome noise, it's going to be a long wait. Also, if there is a...

Here's my thought process for the ME/genetics question. Imagine that the critical part of ME's mechanism is some structural component, such as astrocyte dendrites. Maybe it's the length or diameter--or the length/diameter ratio--or the number and length of microtubules in those. Those numbers...

I think the answer to that is: not really. There are probably too many factors involved. Maybe someone's chance of triggering ME due to a certain covid strain was 23.17% on a certain date. Age that person 6 months more and the probability could be quite different. My ME seemed to trigger on...

One thing to consider for very small dwellings: moisture control. In a large house, likely with plenty of air leaks, moisture is unlikely to cause problems. In a tiny house, it can be a serious problem. Just one human puts out a lot of moisture. When it's cold out, an overlooked thermal...

I expect there's a lot of variability in fingernail hardness, so "just right" might depend on the person.

My guess is that we have a predisposition to develop ME. Having a 90% or .01% chance of developing it at some point in your life when you encounter some set of factors doesn't make it inevitable. Mr. 90% might not develop it after covid, due to some factor, while Mr. .01% does develop it. So...

For roof and exterior cladding, I recommend white metal. Any color other than white significantly raises heat gain. A bucket toilet, with or without a separate pee bottle, works, and is smaller than a composting one. There are various options for minimizing odor. I keep mine outside, and...

It seems like an obvious question regarding ME. My guess is that some--perhaps many--researchers considered the question, but in their preliminary exploration, they concluded that that path of research didn't have a high probability of success. Too many unknown and unknowable factors. This...

Too many unknown factors. If a spice could block my PEM, there's no reason why a spice couldn't lower the threshold for PEM for someone else. Maybe for some people their threshold for physical triggering depends on what cognitive exertion had preceded it, or followed it. Is the effort of...

Also the opposite in terms of why do some PWME encounter the same triggers and not get more severe. You'll have plenty of reports that people became more severe after physical exertion, yet there are others who do even more exertion, and do it fairly frequently, yet don't get more severe...

Have been reported, but what about verification of those claims? May, and may not. There's no real evidence supporting or contradicting their involvement in ME. While some of those things may be involved in ME, or may be involved with symptom severity (but not directly part of ME) in a...

My first thought is that severity is due to some control subsystem. Maybe it's a change in the number of receptors on certain cells, or the number or position of microcapillaries supporting certain cells, or the number of neurons carrying a certain signal. That subsystem, or part of it, might...

The whole argument is about poorly defined things, using poorly defined words. We can't clinically measure motivation, apathy, fatigue, etc. I often feel motivated and even enthusiastic about starting some project, but when faced with actually soldering components or whatever, I feel...

One difference is the availability of the tool. You can buy lab equipment and do self-diagnostics or create your own pharmaceuticals, but neither those tools or the knowledge to use them is readily available. Medical specialists can be considered a tool for diagnosis and treatment, but are...

I consider triggering ME on muscle or tissue damage as reasonable. I think it's immune activation that triggers ME, regardless of what caused the activation. The specific type of activation (t-cells, or b-cells, or whatever) probably matters. That brings up a question: have there been many...

I'm expecting someone to set up an AI "Natural Health expert" to support the alternative health industry, convincing people to buy supplements, homeopathic treatments, etc. It would be trained on what's legal and illegal to say, to avoid making convict-able offenses, but that leaves lots of...

I'd apply junkification to arts too. When I look at "top 100" lists of books, music, shows, etc, to me the rankings have nothing to do with quality of the art, but rather media exposure of the work. Someone shitting on a canvas can get more media attention than someone who paints a really...

I find it very difficult to determine where pains or other feeling originate. I recently hurt my back, and really have no idea whether it's muscle, connective tissue, or spinal disks ... or something else. I'm guessing that's a common failing in humans; our feedback system is simply messy...

I can easily see AIs providing confirmation of beliefs rather than valid information. Do those AIs in those situations provide information that counters weak or false beliefs. Is the AI's goal to help the inquirer, or just to make them happy with the responses?

It reminds me of those corporate "new strategies!" that jokes are made of. Without an explanation for how it will improve research, it's just an empty headline.