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Thank you for the gift of an enormous amount of work chasing references to "facts which make [my conjecture] wrong". You've given me more to think about in one post here than I've seen over the last 6 months. Lots of homework to do. Thank you! -steve

Well said. I actually hope I'm wrong. If my conjecture is correct it will take medicine 50 years to accept. People need an objective test, and treatment, much sooner than that. No matter how it sounds, I'm really here seeking facts which indicate my conjecture is wrong. Facts are really...

I concur this is medicine's belief. I realize Oxygen molecules cannot be brought into a cell by an ATP-ADP pump, for obvious reasons But the supply of oxygen is too critical to the function of the cell, and the cascade of consequences if there's not enough too severe, to be left to chance...

You did absolutely, positively the right thing. I had picked the thread about criteria for ME/CFS hypotheses from May to read every post of, both for background and to get a sense of the style of this forum, before making the first post. And while I can handwave around the rest of ME, it's PEM...

Thank you. I clearly have more reading to do. And I am not arguing that myoglobin isn't loose inside the cell with a critical role in transporting oxygen within the cell. I'm simply asserting that there's a gap in medicine's knowledge, an assumption that oxygen diffuses from the blood into...

You are correct. I am using too simple a model and jumping to a conclusion. Thank you!

My conjecture, and it is only a conjecture, describes a mechanism by which a molecule acting as a hapten -- a well known mechanism in allergy, responsible for poison oak/ivy/sumac reactions -- lands on the opening of a tunnel a cell uses to bring in oxygen, and the immune system destroys the...

Thank you PEF isn't PEM. PEM is a temporary or permanent reduction in the body's ability to make and use energy, in response to use of energy above a threshold medicine can't measure. I don't experience PEM (I have a different complex chronic illness). I do experience PEF, although a lot...

You probably know more than I do. I only found out myoglobin and neuroglobin exist about 6 months ago, although I had been looking for what filled that role for about 2 years. I am ignoring the role of myoglobin as oxygen transport within the cell, and focused entirely on its role efficiently...

This is a detail I hadn't provided yet. In a healthy person, there would be a circulating protein in the blood albumin with a binding site for such a molecule, which would hold that molecule in the blood albumin for however many hours it took the detox system to get rid of it. In a healthy...

Thank you for reading even once. This is a really, really different way of looking at PEM It's based on a really, really different way of looking at the human body. There are basic assumptions medicine makes about how the human body works which would be invalidated if this conjecture turned...

My conjecture is that PEM is progressive autoimmune destruction of myoglobin (muscle) and neuroglobin (neurons), which occurs when (1) a molecule shaped to fit and get stuck on the oxygen storage site of both globins gets loose in the bloodstream, and (2) the immune system learns to recognize...

New here. An ME blogger suggested I bring this idea here for discussion. Will leave out 9/10ths of this idea, looking to see if there's interest in discussion, and most importantly...facts which make this wrong. There’s a protein called myoglobin. It is expressed on muscle cells. One end of...