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Really glad to see phospholipid research being done in ME and this is really great work, well done! I am not an expert in this so please correct me if I get anything wrong but I wonder if the PTDSS1 signal could reflect a long-term membrane adaptation in the parental B cells rather than a de...

My endometriosis symptoms went away completely when I recovered from ME. So I do believe they are connected. My reactive hypoglycemia also stopped when I started to feel better and there is research showing that endometriosis patients have reactive hypoglycemia due to increased insulin sensitivity.

Since this study used serum rather than plasma, could it be that certain factors potentially involved in earlier ‘something in the blood’ findings were lost or altered during clotting? I’m wondering if a plasma-based assay might still reveal effects that serum can’t capture.

You have definitely piqued my interest! Very interested in testing the hypothesis. I've emailed you :)

I looked at the thread and it's interesting that you were suggesting all of these things several years ago. It is a shame there isn't much research by ME scientists into cell membrane dysfunction, as I don't think it would be the hardest thing to research- I am sure there are ways to study the...

Did you search on the webpage or click on the pdf and download it? There is a mention of PEM on page 9.

The new hypothesis still includes the concept of downregulated norepinephrine transporters leading to high extracellular norepinephrine, causing downregulation of beta 2 adrenergic receptors. In the study, they were given clonidine for 9 weeks. However for me, the treatment I took to correct my...

I made a video for the second part of the hypothesis (the part focusing on phosphatidylcholine), it might be easier than reading through the paper.

I don't think you can work out what subtype you are based on VMA levels alone. That's because the norepinephrine that's broken down from inside the neuron is also converted to VMA, just like the norepinephrine outside the neuron. Also there are other factors like the breakdown rate of COMT and...

Hi. I made a hypothesis video which you can find on the following link- https://www.s4me.info/threads/me-hypothesis-noradrenergic-neuron-dysfunction.40280/ At 8.40 in the video I discuss overtraining syndrome. The idea is that there is a problem with regulating extracellular norepinephrine...

Thanks for the tag, that's interesting research, definitely worth more research being done into the diabetes connection!

I think there could be subtypes of ME, and a small subtype who have increased insulin sensitivity may benefit from statins. I think there could be a different ME subtype who have insulin resistance, and I am not completely sure what the effect of statins would be in that subtype. I made a video...

Some research on the effect of statins on glucose uptake and insulin resistance- https://drc.bmj.com/content/2/1/e000017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876152/ However in this paper, they found that the increased insulin resistance seems to be more pronounced in insulin...

There is evidence of increased nerve sensitivity to insulin in endometriosis- https://www.fertstert.org/article/S0015-0282(01)03088-6/fulltext#:~:text=Patients%20with%20ENDO%20are%20membrane,debilitating%20symptoms%20of%20the%20GIT. This ties in with the insulin hypothesis I posted a few weeks...

Oh that's great, thanks for posting your results! As you said that you are not sensitive to carbs, it would make sense that your fructosamine level is normal, but it is still good to confirm and not make assumptions. Hopefully I will get some more results soon from people who have signs of...

Oh that's great, look forward to seeing your results!

Well, I assumed people would be likely to self select anyway, as people who have had glucose issues, higher fasting glucose, bad carb reactions would be more likely to suspect insulin resistance and want to take part. So I figured that if I tested a certain number of these people with indicators...

In the UK you can book and pay for a fructosamine test on Medichecks, and go to a clinic to get the blood test done. But the total cost is £90 and then the HbA1c test would need to be done around the same time, it might be possible to request this with GP. HbA1c can also be done with Medichecks...

After the really interesting recent study by @Chris Ponting showing some markers of insulin resistance in ME patients, the question arises, why would the HbA1c not be indicating insulin resistance in these patients? I have seen Continuous Glucose Monitor (CGM) charts of people with ME, and...

I am just hypothesising and could be completely wrong but maybe it should be considered that the HbA1c might not fully capture certain forms of insulin resistance. The HbA1c test measures the average blood glucose levels over approximately the last 2-3 months by assessing the percentage of...