We did Irg1 knock-out. This is different from knock-down. In case of knock-down, you are decreasing protein expression by targeting mRNA. Usually...
You don't want to use SDH inhibitors as therapeutics. They can be helpful in some cases. But one of the side effects is Alzheimers.
This all is ongoing and experiments are running. I have reason to believe (I have experimental proof that is not yet perfect) Prdx3 is not...
Please allow me to adjust some of the points. 1. You are absolutely correct. The problem arises especially when people use derivatives of...
@Jonathan Edwards @jnmaciuch Itaconate uptake has been shown for number of cell types, including T cells. But, one thing has to be considered and...
One type of glial cells are microglia. These are essentially brain macrophages. They are innate immune cells that can get activated by myriad of...
Hi Jonathan, This is indeed very deep and requires some thought. I agree that cellular basis of ME/CFS is very much needed to be understood....
Max Artyomov (priciple investigator in this story) has a talk in Harvard seminar series. It just came to my attention that it will be streamed on...
Thank you! This will help for sure.
Thank you, I'll do my best to get to this. Currently working on many fronts. plus i'm getting ready to speak to leaders in ME/CFS research. Sorry...
Here is a little backstory of our discovery. It is public and short. Should be accessible to everyone....
I like this idea. Since ME/CFS is mostly self reported (correct me if I'm wrong, please) this would be a key step in understanding and...
Thank you! Let me know if there is more I can explain.
I understand, you make a good point here. But, what can be done is to record the meeting and people can come back to it and listen to it in bite...
If you'd like, I can organize a mass zoom meeting, where I will explain our findings in more detail so that everyone can understand. Would you be...
Sorry for that. Open access is crazy expensive. My paper is also available on researchgate with the fulltext....
Hi tuha, This is wonderful. Can you share who's the long covid group? We are planning things on the fly at the moment. But this could be an...
Thank you, I appreciate it. This is very important thing to answer. The delay can be explained by the fact that expression of Irg1 doesn't really...
@jnmaciuch I will answer point by point Are you saying that natural itaconate likely only inhibits interferon production via upregulating ROS...
The way CAD (I'm more used to IRG1) activation is described is not exhaustive. It is one of the pathways that can induce it. The reason I'm saying...
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