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Thanks for the suggestion. I suspect that my changes are not part of a gradual change in my migraines as they are so tightly tied to the gepants. On some days on rimegepant, I had a moderate migraine followed by full post-drome/PEM that was much worse than the migraine. This had never happened...

Thanks, @Ryan31337 and @Nightsong for your insights. I've had migraine for seven years without reading too much about others' symptoms and hadn't realised how close to PEM a postdrome could be (or at least the description of it). But I noticed that for you and @MrMagoo your PEM is different...

Hi I've had ME for decades, but my migraines only started 7 years ago. The migraines are very disabling and usually last for almost a whole a day. I'd always suspected that migraines interacted with my ME, and both migraine and ME consultants thought this was likely. Recent experience with a...

I hate talking about my experiences publicly and some people recognise me from my name here, hence the anonymous user name - but I really like this point and want to add something to it. Once, I was visited at home by a consultant liasion psychiatrist (who had all the usual views). I explained...

Meanwhile, in the real world of the drug trials, blinding remains an issue: My dad has Parkinson's disease, and I was recently reading about the GDNF trial. This was a "promising" new treatment but there was no significant difference between placebo and GDNF at 40 weeks (subjective outcome...

This isn't marking your own homework, it is revising the marking guidelines to allow the answer you have already given (and intend to keep on giving). It is absurd that the use of randomised, uncontrolled, unblinded trials with subjective outcomes can be given the green light by someone someone...