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So they're just replicating citation 36. They reference citation 36 as "herpesvirus are found in saliva in CFS patients" But it's more than that: "Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue." Why wouldn't...

People that exercise less would have less elasticity in their vessels and thus less perfusion. So you'd have vascular narrowing and low blood volume - not a good combination. For further reading: Alosco ML, Spitznagel MB, Cohen R, et al. Decreased physical activity predicts cognitive...

https://en.wikipedia.org/wiki/Betteridge%27s_law_of_headlines

I'm not discounting orthostatic intolerance or the sympathetic nervous system's role in the illness. In reference to the paper where there are no differences between mild / severe illness, but the same would apply to the eponymous post. Mild CFS patients and sedentary people have the same...

"This would be a very very good high school science fair project." Put me in, coach.

So an increased level of motion activity not necessarily correlated with steps? Like going to outpatient visits for cyclophosphamide?

There's something upstream of kynurenine that's wrong and increasing it won't (shouldn't) help. This is all theoretical so my word is as good as theirs, they are not doing intracerebral dialysis measurements on humans any more than I am, nor are there any results for imaging. Tryptophan is...

You do a 40/40 Phase II trial placebo-controlled with actual objective aerobic testing, exclude anyone with disease course variation and you slam it through in a year. Do it this paper's way and you can finesse natural disease course variation without a placebo and harness the placebo effect...

Most athletes were never going to get depression in the first place, even if they were completely sedentary. They have young fit parents without depression, some of whom were professional athletes. It really screws up research. Sam Darnold is an NFL quarterback that got sick with mono pretty...

Ironically, the RBC study and this study have the same mis-attribution of causality. RBC variance is a function of physical activity, even in healthy people. I am not going to hold a student's thesis to a higher standard than a trial published in the Lancet though.

Symptomatic presentation increases by age as I mentioned earlier and since initial severity dictates permanent illness, the time matters.

Saliva in cans is what I mean by dirt, but to be esoteric the diffusion of children into reduced points of contact from their neighbors creating an isolated environment - instead I said dirt. In the 1970s the average age of seroconversion to mono was 3 years old and now it’s 17. In the 80s it...

Someone knows the head author? Looking at the wrong variables. Students that develop CFS will have more vaccines by quantity and less sex partners and as a result have higher humoral immunity at baseline - just in this cohort. Are vaccines responsible? No (yes), as it could be just a function...

The author has a financial interest in its success - a practice prescribing LDN is extremely profitable especially if you have a partnership with a compounding pharmacy. Even though he lost his license he still has a massive patient base. He really should move his practice across a land border.

This is what I was looking for, thank you for keeping me in check. That is not the selection problem - Cohort is mostly self-referred to a clinic only known for LDN. Insomnia would increase alertness / vigilance scores without providing actual improvement, which is why the 6 point scale was...

Almost everyone discontinues LDN and its efficacy rates are miserable. They would know that if they did a chart review. It works in fibromyalgia because when you come off it your opiate receptors are more amenable to endogenous opiates - too short a half life.

Why? She’s a plant biologist specializing in mitochondria, of course she thinks it is metabolic. Has she taken gross anatomy? Phys? Neuroanatomy? Endocrinology? histopathology? I assume so. It would be like me publishing papers in botany - I could maybe i had to take plant biochem - wouldn’t...

High approvals aren’t good. Giving money to cell biologists and immunologists for a neurological Illness because they can bid lower is what’s happening. Lower consumable cost. You’re not going to fix peoples outlook on CFS and increase funding. It’s not even in their top 100 priorities. You...

Splenectomy in general lowers immune reservoir for B-cell production and is a focal point for herpes virus infections. It is not just general immunstimulation due to a viral infection as shown in acute splenomegaly. These cells are co-localized with cytochromes with are modulated by that by a...

2011 paper Sustained 20 years, zero citations. Zero. “A unique case of coincidental splenectomy for trauma during chronic fatigue syndrome (CFS) is presented. The patient had a two-year history of CFS prior to her involvement in a road crash. Delayed rupture of the spleen ten days later...