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The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity Ruiz-Pablos, Manuel; Paiva, Bruno; Zabaleta, Aintzane Abstract The prevalence of autoimmune diseases in contemporary human populations poses a challenge for both medicine and evolutionary...

New article we have published: “The Genes of the Survivors: How Immunological Inheritance Drives Autoimmune Diseases, Long COVID and ME/CFS” Certain ancestral HLA-II haplotypes (DR2–DQ6, DR3–DQ2, DR4–DQ8) provided advantage during epidemics because they produce strong and rapid immune...

How my father developed symptoms of ME/CFS and Long COVID after treatment with ICIs When I wrote the article comparing ME/CFS and Long COVID with the symptoms developed by some patients treated with ICIs who carry HLA-II susceptible alleles, I never imagined that my father would later receive...

New Article Could Reveal the Origin of the Long COVID! Model of the new article. 1. Immune Sensitization and Inflammatory Response: * Proposition: the S1 subunit of SARS-CoV-2 can induce a form of “sensitization” in the immune system. This means that, following exposure to the S1...

Why is autoimmunity triggered by viral antigens the most likely cause of Long COVID, Myalgic Encephalomyelitis and Post-vaccinal Syndromes? New articles published this July support our hypothesis: Increased proinflammatory cytokines. Elevation of cytokines such as IL-6 leading to muscle...

Old Articles that, if Published Today, Would Be the Key to the Development of Long COVID, Myalgic Encephalomyelitis and Post Vaccinal Syndromes Study on Hypothalamic-Pituitary-Adrenal Axis (HPA) in SARS Survivors An article in (2005) investigated endocrine sequelae in SARS survivors, revealing...

ICI-treated individuals who develop hypophysitis may hold the key to the development of ME/CFS, Long COVID and post-vaccinal syndromes In the field of immunology and cancer treatment, Immune Checkpoint Inhibitors (ICIs) have revolutionized cancer therapy by activating the immune system to...

Proposed Action Protocol for New Cases or Less Than 6 Months Old with Long COVID, ME/CFS or Post-Vaccine Syndromes with Pituitary Damage: ➡️ Initial Evaluation: Laboratory and Imaging Tests: Pituitary MRI, Serum cortisol, saliva cortisol, 24h urine cortisol, plasma ACTH, DHEA-S and stimulation...

New article: the connection between Long COVID, Myalgic Encephalomyelitis, and post-vaccinal syndromes lies in the development of an Autoimmune Hypocortisolemic Syndrome I am excited to share with you our latest paper entitled "Hypocortisolemic ASIA: A vaccine- and chronic infection-induced...

It is written so that it can be understood by the general public. Clearly thousands of pathways are involved in the immune response. But in terms of genetic factors involved in weakness against infections, the development of autoimmune diseases and their relationship in distinguishing the self...

Does this model explain the dysautonomia present in these patients? Yes, here is a breakdown of how the model can generate dysautonomia: 1. EBV infection: the inability to adequately control EBV latency I cells could result in chronic inflammatory responses, which disrupts immune system...

Good afternoon everyone, I am enclosing below in summary the main points of our review and the questions that the model could answer about these diseases. Many people wonder why EBV, the Epstein-Barr virus, and not another virus, is the main trigger of the symptomatic picture of ME/CFS and...

NEW ARTICLE PUBLISHED! Unraveling the Connections Between EBV, Long COVID, and Myalgic Encephalomyelitis After months of meticulous review and analysis, I am proud to present a study that explores the deep connections between Epstein-Barr virus (EBV), Long COVID and Myalgic Encephalomyelitis...

As soon as I can I will respond to your comments. In the meantime, here are some of the answers I have posted on Twitter: “After so many years of work and as a post Epstein-Barr virus infection ME/CFS sufferer it makes me really happy that they have put our article on the cover of the August...

I would like to share with you my latest review article. The Epstein-Barr virus (EBV) has long been known to be behind the development of autoimmune diseases, cancer and is even suspected to be behind the development of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Long COVID. But it is...

After a long time and a lot of work, our hypothesis on the development of ME/CFS following an Epstein Barr virus infection has finally been published...

Rosario Montero and I would like to thank Solve ME/CFS Initiative for trusting our project and funding it. Also to Dr. Bruno Paiva and his CIMA team for carrying it out. And what to say about all those patients and relatives who have donated to the study. Without them this would not be possible...

@Jonathan Edwards @Trish Thank you so much for the welcome. Sorry to take so long to answer. I have a lot of work and I'm sick. The problem with CFS/ME is that many patients with the same symptoms may have different causes. That is to say, the evasion mechanism that I comment on in the...

Good afternoon, I am Manuel Ruiz, medical student in Spain and I am sick with CFS/ME. Together with my girlfriend Rosario, graduated in Medicine from the Complutense University of Madrid, we contacted one of the best research centers in Spain, CIMA, to carry out the project described below...