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Low stamina was the main thing that tipped me off that something major had changed after a stomach bug that triggered my CFS ~ 20y ago. Sure I had tons of other weird symptoms all of a sudden, but this one really stood out to me. Before my trigger I would jog / run everywhere, rather than walk...

Didn't know that. That seems like quite an important finding then that is not talked about. If they deemed it not worth the sides then the effect was probably not that great though, hence why it is not talked about. That being said, corticosteroids working does resonate with my personal...

I do find some of the autoimmunity theories out there quite compelling, especially the one by prof. Scheibenbogen. However, something that needs to be reconciliated is the fact that immune suppressing drugs have failed to show results (Rituximab, Corticosteroids, etc.). I do not know how, but...

Yes the researchers need to be commended for doing this study. They could have easily skipped the control group and gotten a positive result (due to placebo). Instead they choose to make a robust and properly designed study, unlike many others who do these kind of uncontrolled studies either to...

In the video presentation Phair mentioned that according to the hypothesis the brain uses it's own neurotransmitters for energy (since some of them are amino acids). I think that this could explain PEM from mental activities quite well. Namely, when you engage in those activities you use up the...

I haven't noticed much benefit from high protein diets and I haven't heard of many others benefiting. It is still an interesting theory though, maybe all those additional amino acids you get from a high protein diet can't get to the brain where they are needed?

If Sarin is indeed the cause of GWI, then I guess we need to figure out how Sarin exposure leads to a permanent CFS-like state. I'm guessing it is likely damage to a certain part of the brain. After all post concussion syndrome is quite similar to GWI and CFS. The bad news though is, if it is...

When it comes to CPET tests I think we should not focus on the drop in performance that much, but more on the failure to increase performance. It is obvious that healthy people can increase their muscular and cardiovascular endurance trough training, but it seems to me that in people with ME...

Yes it is logical that it should be higher. But I just a read study that said that half of the participants had normal lactate at rest. I think lactate abnormality should be more pronounced when exercising. And even more when comparing CPET tests. Another study showed no lactate reduction on the...

Well that goes back to my original question. Maybe indeed they just mask it, but maybe they affect one or more things that are wrong with us in a positive way, albeit temporarily. Like you said maybe your hormonal response to stress is blunted, hence why you don't experience the same benefits...

Yes, indeed being in such a state could trigger PEM if one is not careful, that's for sure. What I am interested in however, is how stress hormones could improve our condition that dramatically and quickly.

I have noticed that adrenaline or some other stress hormone (possibly cortisol) dramatically improves my fatigue and many symptoms temporarily. To give an example, let's say I get a sudden attack of fatigue or sleepiness, if I don't do anything I would be in bed after a few minutes. However, if...

No wonder, when I got sick, the most objective sign that something was wrong was my sudden reduction in cardiovascular endurance. Literally overnight I could no longer do cardiovascular activities without getting exhausted prematurely, while just a few days before that I had no problem doing...

Could anti-histamines also be helpful in a subset of people with ME/CFS? Any anecdotal reports? I am pretty sure that I have an intolerance to high histamine foods (eg. cheese), I wonder if taking an anti-histamine would help.

By the way, I've read that regular exercise increases NO levels. If their theory is correct, does that mean that mild / moderate exercise could be beneficial if it doesn't trigger PEM? What about the results from the GET studies, maybe this has something to do with the positive results?

For me it's the same. Mental exertion doesn't just trigger fatigue, but other completely unrelated symptoms, like muscle pain that you mentioned and others. Which leads me to a question I have asked before: how could an activity where the brain is involved lead to symptoms that seem to have a...

Some things we know about ME/CFS support his hypothesis. Namely how you could get PEM from cognitive exertion alone implies that something is wrong in the brain. But others suggest a systemic problem. For example abnormal results from cardiovascular challenges (eg. CPET). Quite a few of those...

Mg Oxide is very poorly absorbed, I remember reading one study where Mg Citrate's effect on blood Mg levels was several times higher than Mg Oxide. Intracellular Mg levels weren't different between the two though. Maybe in order to increase them you would need a prolonged supplementation of...

Didn't another thread mention something being wrong with nitric oxide (NO)? I'm still trying to figure out if magnesium helps me. I'm not certain if it's a coincidence or not, but I've noticed an improvement after prolonged supplementation (2 weeks +). I've noticed this a few times after...

Maybe it is possible. I don't think there has been much or any research on how cells react to low level hypoxia or reduced micro-circulation. It could simply be that the damage takes some time to present itself.