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  1. ZeroGravitas

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    (13) General curiosities: (a) Can HHV-6 DNA show up sometimes in whole genome sequencing? I assume this is deliberately filtered out of the final data, even if its chromosomally integrated...? (b) How close are we to having a working CRISPR system that could remove HHV-6 from humans (in...
  2. ZeroGravitas

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    Questions asked and replied to on this tweet. Prusty's responses in quotes: (1) Does time frame of transfer effect suggest mechanism for patient's 1-2 day delayed PEM, crashes, etc? Naviaux's previously said [2018] that "Mitochondria change their function rapidly under stress. Within...
  3. ZeroGravitas

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    OK, so here's my paper summary previously posted here on the other forum (a couple of tweaks noted): I think this is the most exciting study since I first came across the hypometabolism (aka dauer) metabolomic studies and Naviaux's Oxidative Shielding, CDR (Cell Danger Response) and Healing...
  4. ZeroGravitas

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    ....Aaand, I killed the thread. :oops::rolleyes: May as well stick some nails in the coffin: Cort just published a nice write-up on a paper from November 2019 by lead author Nuno Sepúlveda [SimmaronResearch]. Full paper text here [NCBI]. "ME/CFS as a Hyper-Regulated Immune System Driven by an...
  5. ZeroGravitas

    ME/CFS as a hyper-regulated immune system driven by an interplay between regulatory T cells & chronic human herpesvirus infections (2019) Nacul et al.

    Cort just published a [SimmaronResearch] article on this work and author Nuno Sepúlveda.:) I'm not sure if it clarifies anything discussed above. I'm wondering if Prusty's recent HHV-6 work precipitated Cort's posting at all - it is mentioned.
  6. ZeroGravitas

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    Well, I sneakily linked it in that quote already [PhoenixRising].;) I still have some refinements and additions to edit in, based on (your) comments, etc. May quote paste it here after.:) I meant it more as an educational summary, that I didn't think most here would benefit from... Lurked here...
  7. ZeroGravitas

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    I did a good...?! :eek::oops::) When I commented asking on his HR blog post, Cort said it was just Naviaux he talked to for that post. Kinda surprised me, as this study seems like Prusty's baby and he's communicative (on Twitter at least). Not sure exactly what aspects Bob contributed to the...
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