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  1. Gdel

    Is ME a metabolic problem or a signalling problem?

    @Jonathan Edwards Hi Prof Edwards, I was just going over your profile on ME Pedia...so you're definitely ahead of the game than most. Agreed then, we are at base one.
  2. Gdel

    Is ME a metabolic problem or a signalling problem?

    @butter. Agreed. I view the present situation with ME research is that they're trying to figure out "one elephant"....but i think there may be "many elephants" (not just "one ME", but maybe several MEs). Rational sub grouping will help bring better focus and subtype specific research, which...
  3. Gdel

    Is ME a metabolic problem or a signalling problem?

    Thanks, agree that oxidative stress and low oxygen are 2 different things, however I go by conclusions made by researchers (quoted in my previous response) Ref pro inf cytokines, you will find several studies showing increased levels of IL6 , TNF-A, IL1 B. So I would not agree that "there is no...
  4. Gdel

    Anyone any experience with probiotics?

    Just reading this thread now and interested in learning from other user's experiences. My gastro just started me on Mutaflor for my IBS/SIBO and it seems to be helping me
  5. Gdel

    Is ME a metabolic problem or a signalling problem?

    Hello Trish, Thanks for your response. This is going to be a long reply, since I am citing research studies & putting my inferences (please read when able, since this is data heavy) Here are my thoughts: 1) Low Oxygen/Hypoxia - There are several studies that indicate oxidative stress/low...
  6. Gdel

    Is ME a metabolic problem or a signalling problem?

    Hello, just reading this thread. I'm new on the forum, so apologise if something is out of place (still trying to navigate this site and see how things work here)…. My 2 cents on this: I think its both. 1) Metabolism problems: High PDK (Pyruvate Hydrogenase Kinase) levels are supposed to...
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