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But in my opinion using CPET is really a bad idea, given what it will do to someone with ME. So it's good that they didn't do CPET in the study and at the same time it's bad? If they were to make an earnest attempt to find low functioning mitochondrial in control groups and failed then this...

If you consider that mitochondrial function could be a result of fatigue, then you need to find some way to disprove that? Isn't that science. Come up with a theory and do your best to disprove it? Sadly I see little evidence of this approach within and outside of the science realm (though I...

To my way of thinking, that's the paper's biggest issue. I just wish we could convince all researchers to use ICC. But then maybe that's a topic for another thread?

I'm wondering if that paper doesn't just show that low mitochondrial function is only a symptom of fatigue and not that fatigue is a symptom of low mitochondrial function? If you take a normal healthy human and run them into the ground over a week, then test them I suspect that you might find...

I'm no biologist and I lack enough energy to become one. I'm just trying to apply my experience in logical deduction to find how concrete the findings are. Someone suggested to me that you could make a theoretical argument based on the result from Impact of Lifelong Sedentary Behavior on...

Forgive me if I've missed something stated here or presented in the paper, but to me I don't think the researchers have found what they claim to have found. The title claims they have found a causal relationship between low energy production in immune cells and CFS, but from what I've read I...