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The hype is not created by me. This is a preliminary, proof-of-principle, pilot pragmatic trial, as the title says, and it is published in a Journal called "medical hypotheses". The finding that pre-treatment characteristics seemingly can differentiate between patients who did and those who did...

citation from the manual of the MedCalc programme (Schoonjans, MedCalc Ltd. Ostend, Belgium): "The goal of logistic regression is to find the best fitting (yet biologically reasonable) model to describe the relationship between the dichotomous charateristic of interest (dependent...

Thank you, those participant(s) who consider my scientific work and publications "shoddy". Nonetheless, my work ranks at the 97th percentile of scientific publications according to "Research Gate". Clearly, I work with patients, and ethical reasons limit the kind of "clinical experiments" I can...

This is the result of statistical analysis of 34 "cases" studied today. The power power of the (p) value (p=probability) to discriminate between responders and non-reponders is highly significant (P= 0.0016). This is an observation. Additional studies and tests are necesary to try explaning this...

What has been shown is that stress (including psychological) induces increased secretion of Nuclear factor kappa B. By definition this factor affects DNA.

The interesting aspect of this study is the fact that the day-night rythm (nycthemeral biorythm) may be disturbed. This rythm largely depends on the sleep-wake pattern influencing the thalamo-hypothalamic-adrenal axis. If the sleep pattern is disrupted (as is commonly the case in ME/CFS...

There seems to be some confusion. The "total FSS" is calculated by adding up the score of each separate item (e.g. the sum is 58). This sum is divided by 63 (e.g. sum= 58, divide by 63= 0.92). Now multiply this by 7 (e.g. 0.92 x 7 = 6.44). The value 6.44 is the total (or average) FSS. Introduce...

The value coming out of the formula is lpgit(p) which should be converted to (p), being the statistical probability of being a "reponder".

It is Always nice if comments are based on knowledge , which is evidently not the case with this comment. It is not by rediculising that you can make a scientific argument.

4 responding patients have been taking DCA treatment since 12 months, and continue to benefit.

As you know I have published an article on a hypothesis. I have also written a book in which about 70-80 pages are devoted to explaining the pathogenesis of ME/CFS which I find plausible. Regretfully, the book is in Dutch. So, it is not possible to summarise all in one paragraph. It has been...

Negating OBSERVATIONS is funny indeed. But it is OK as long as you are amused.

The lack of universally effectieve treatments is due to the fact that ME/CFS is not a disease, but that the name covers many different diseases involving several pathogenic processes.

Thank you for the suggestion. Random variations seem rather improbable considering the very high level of statistical significance. But, all this needs continuous reasearch and investigation. For me, our finding suggests that what we observe is more than just by "chance".

Somatic reaction are controlled by the autonomous system, with its orthosympatic and the parasympathic components. The activity of these are regulated by the thalamus, which is part of the diencephalon. There is convincing evidence that the function of the diencephalon is deregulated, and the...

This is indeed a well-known fact. Nonetheless, it does not make these feelings less important for the patient. Who are we (as doctors) to reject what the patients experiences. Recall bias and other psychological elements my tend to aggravate complaints and symptoms.

In fact, using a non-registered chemical substance for medical treatment is illegal. This is not at all related to the patent, though the patent may help in the process of registration. If the registration would fail, it might be possible to use the extract of Asparagopsis taxiformis. But that...

The formula has, indeed, slightly changed, since e.g. duration of disease (which had very low impact) was not maintained when larger numbers of patients, some with very long durations of disease were included. The strong discriminating power of the formula is a remarkable finding. The formula...

Several papers, and my own experience from history taking, suggest that "things in the past" and lack of emotional binding during infancy and youth are reported by some patients. This, evidently, is their own subjective feeling. Also patients mention that they feel vulnerable when exposed to...