Search results

I thought this may be of interest as I think likely many of the issues raised in this article are also applicable to microbiome research in ME/CFS, and probably biological research in ME/CFS in general. Such as studies with high dimensional data with small sample sizes, "absence of specific...

Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism By Kevin J. Mitchell, Darren L. Dahly, and Dorothy V.M. Bishop Summary The idea that the gut microbiome causally contributes to autism has gained currency in the scientific literature and...

I think to be truly useful it would need to be done during PEM, which is what primarily disables in ME/CFS, rather than immediate fatigue. Even then it seems a bit hard to interpret, as far as I can see. It could be that there's a non-central cause, but that also affects the Central Nervous...

I've wondered in the past who would have had an idea of what the trial outcome data said, before they changed the statistical analysis plan. They state that they changed the statistical analysis plan before analyzing the outcome data, which is probably true. According to the 2007 protocol: "All...

Here is the video of this: And here's a chatgpt translation of the subtitles (can't vouch for how good it is): Reporter: "Okay, let’s switch over to the topic of health. We’ve been getting quite a lot of questions about Long Covid and ME/CFS. Fabian sent an e‑mail asking: When will your...

I think it's because the zeta-potentials are negative values, and the "Change in zeta-potential" would have been calculated something like: (NaCl zeta potential value minus zeta potential value with no NaCl) divided by zeta potential value with no NaCl. That would give a negative number minus...

I think what you're saying here makes sense. I haven't looked into this thoroughly, but they cite "Core GRADE 2: choosing the target of certainty rating and assessing imprecision" (2025, BMJ), which states "The location of the point estimate of effect in relation to the chosen threshold...

So the idea is that even partially reducing signalling from the peripheral nervous system may give an idea whether that's mediating central sensitivity in fibromyalgia?

Wouldn't these have limited effect in fibromyalgia due to the widespread nature of the pain? eg. you would have to block all ganglia, which isn't feasible. Maybe it could still indicate something, though

This seems like a good paper. The Walitt paper is odd. It appeared to be assuming that the extra fatigability in ME/CFS should be immediately apparent, when post-exertional malaise is a defining feature of ME/CFS. And then they choose one statistically significant result (and bring it up...

In the methods they state "To mitigate the concern of multiple testing of p-values stemming from the IVW method, we implemented the False Discovery Rate (FDR) correction. A p-value adjusted for FDR that falls below 0.05 signifies a definitive causal linkage between exposure and outcome." But...

This seems like quite a good paper in many ways, particularly how it tries to anchor the hypothesis in features of ME/CFS, and patterns seen in other conditions. Apparently when stimulated by interferon gamma macrophages release neopterin...

Small-ish detail, but the question asked was "Did you experience any harm while doing the LP?", not "Did you experience any harm as a result of LP?", or "Did you experience any harm during or after LP?". If LP does cause harm, you'd expect it to probably mostly occur afterwards, not during the...

I looked this up, and for anyone interested this review: "Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives - PMC" goes through the evidence for the usefulness of leukocyte telomere length (LTL) as a marker of biological age, and seems to take...

Lobbying Cochrane's funders, which are mostly governmental bodies and some charities, seems like possibly one of the best options. Cochrane repeatedly make the point that the entire point of their organisation is "Trusted evidence. Informed decisions. Better Health", engagement with consumers...

The questionnaire in its current state seems flawed in a few ways, but it at least seems better than other questionnaires used in ME/CFS I've seen, which have just been (in my view) blatantly ill-suited for ME/CFS. If this research project at least gets more people thinking about how to actually...

I get the impression that the distinction between "supportive CBT" and "pace-style CBT" may not be as clear as it seems. Both of them would still operate under a similar framework (changing cognitions, behaviours, and coping skills) and goals (doing more of certain things or dealing with certain...

Yes, I read that and wasn't impressed with that. Diagnostic criteria referring to instruments doesn't mean they're "proven", nor does being commonly used. And, they also used scales which were both not validated in any way at all and not commonly used at all. They didn't address that (besides...

I think it's good IQWiG acknowledged how small the effect sizes are in the press release. I think that's something obvious but it's also very overlooked - the effect sizes are very small, it's not clear they have any clinical importance. I haven't read through much of the report because it's...

Thank you for engaging on the forum and getting involved in this @sarahtyson. Apologies if I missed anything in this thread, since I haven't read it in its totality. I assume this is the FDA guidance you refer to: https://www.fda.gov/media/77832/download Something which this guidance is very...