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  1. leokitten

    Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial, 2026, Ostendorf et al

    Surprising to me that it’s taken this long to run clinical trials using plasma cell depleting treatments in antibody-mediated disorders
  2. leokitten

    IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness, Yang et al, 2025

    It’s the dorsal raphe nucleus so it’s serotonin neurons
  3. leokitten

    Hypothesis Glymphatic System Dysregulation as a Key Contributor to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Nemat-Gorgani et al

    So yet another theory paper without any data...
  4. leokitten

    ATP release deficiency through astrocytic connexin 43 in the dorsal hippocampus promotes depressive- and anxiety-like behaviors, Wang et al, 2025

    https://www.sciencedaily.com/releases/2025/11/251126025315.htm
  5. leokitten

    ATP release deficiency through astrocytic connexin 43 in the dorsal hippocampus promotes depressive- and anxiety-like behaviors, Wang et al, 2025

    Depression is a common psychiatric disorder, and increasing evidence implicates the dysregulation of extracellular ATP and hippocampal dysfunction in its pathophysiology. However, whether ATP release is involved in depression and mechanisms underlying this involvement remain unclear. Moreover...
  6. leokitten

    IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness, Yang et al, 2025

    https://www.discovermagazine.com/feeling-anti-social-when-you-re-sick-signals-to-the-brain-are-responsible-48304
  7. leokitten

    IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness, Yang et al, 2025

    Highlights • IL-1β uniquely triggers self-imposed social withdrawal during inflammation • IL-1R1-positive DRN serotonergic neurons mediate social withdrawal • A peripheral-to-central IL-1β relay sustains prolonged social withdrawal Summary Sick animals exhibit behavioral changes that extend...
  8. leokitten

    Aripiprazole - Abilify

    I would say everyone is different, and the fact that your ME normally fluctuates a lot means it's very difficult to reliably attribute symptom changes or new symptoms to LDA use. My baseline ME doesn't fluctuate that much. I've cycled LDA since the beginning of 2021, so quite a number of times...
  9. leokitten

    Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus: a case series in China 2025 GAO et al

    I think the jury is still out as to whether all cases of lupus could be treated targeting CD19, it could be for some of those that didn't respond that they could respond to BCMA CAR
  10. leokitten

    CAR-T therapy

    Either are viable targets for plasma cells, including as well FcRH5 and GPRC5D
  11. leokitten

    CAR-T therapy

    And BCMA CAR T (shown in the cover) to also get at the LLPCs
  12. leokitten

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    It is well known that NK cells are needed for plasma cell depletion of dara, separate from this trial or ME, and we have the clear correlation between response and NK cells/ul found in this p1 study. It's a start and actually a really crucial potential finding when moving forward to any p2 study...
  13. leokitten

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Sorry I thought they made it higher my bad
  14. leokitten

    Long-lived plasma cell (LLPC) theory - Similarities between CFS and Lupus?

    https://www.medicalnewstoday.com/articles/study-links-autoimmune-lupus-common-virus-epstein-barr-infection https://www.s4me.info/threads/epstein-barr-virus-reprograms-autoreactive-b-cells-as-antigen-presenting-cells-in-systemic-lupus-erythematosus-younis-et-al-2025.47139/
  15. leokitten

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    At least here we are finally potentially understanding more why it might not work in some people instead of having no clue in RituxME and then throwing hands up in the air and saying ME isn't B-cell mediated, where here insufficient NK cells are needed for dara plasma cell depletion, and we need...
  16. leokitten

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    A lot of us have high hopes for any DBRCT on CD38 targeting therapy
  17. leokitten

    Evaluation of Interventions for Cognitive Symptoms in Long COVID, 2025, Knopman et al

    I had all my hopes on brain zapping
  18. leokitten

    Aripiprazole - Abilify

    I’m not sure if you are crashing and bedridden a lot while on LDA if it’s going to work for you. I’m housebound moderate normally not severe
  19. leokitten

    Aripiprazole - Abilify

    I don’t have withdrawal effects no. When I stop taking it continues helping for about 2 weeks or so and then around week 3 I come crashing down back to my baseline . It’s not a withdrawal per se even though it can feel like it, it’s just rapidly going from a good level back to where I was before...
  20. leokitten

    Aripiprazole - Abilify

    I used to take 0.25 and go up to 1 mg a day and would have a really good response that lasted two months or so before very slowly reducing over months. I would titrate up over a few weeks. This was 2021-2024. Going up higher than 1 mg didn’t help more. But now I have a big confounding factor...
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