If I’ve understood the hypothesis correctly, PEM would be a downstream side effect of cellular debris triggering immune activation as opposed to a...
Looking forward to reading this and greatly appreciate all of your efforts to solve this awful puzzle of a disease.
Thanks for taking a look. All of this is well beyond my understanding. For what it’s worth, I put the PK tables into AI. After adjusting to...
Thanks. Here is what I found on PK data. Does this tell us anything?
After doing a bit of digging into the AER-002 trial documents, there are reasons to believe the trial design, as opposed to mAbs generally, may be...
No studies, which is shocking to me. It’s approved under EUA for a very limited set of immune deficiencies. EUA doesn’t allow it to be prescribed...
To me, this feels a little like the failed Rituximab trial. There are numerous credible N1s of LC patients cured with Pemgarda. There are several...
Could inhibition of PRDX be the cause of red blood deformability problems observed in ME/CFS? Per Grok, PRDX2 seems to be important for...
Reviving this thread as a result of the recent MIS-C COVID paper that found high TGF-Beta in COVID induced MIS-C. Perhaps TGf-Beta is also driving...
Is this good evidence that Long Covid is not a b-cell autoimmune disease given that it does not skew +-80% female?
So, I’ve been thinking a lot about LC’s relationship to ME/CFS. I have long covid, but not PEM. My guess is they are not the same disease, but LC...
Thank you, @Jonathan Edwards. I always enjoy reading your posts and greatly appreciate your feedback. As a lay person, it’s very interesting, and...
My hypothesis is that Long Covid is caused by shedding of ACE2 receptors leading to prolonged down regulation of ACE2, disturbances in the RAAS...
Very unlikely. No diseases that features confirmed viral persistence look anything like LC.
I have two questions for anyone who might know the answer or have a deeper understanding of the science. First, after reading the paper...
So forgive me if this is a patently stupid question or has previously been discussed. I’ve looked and don’t see anything in archived posts here...
Per Davis’ speech, not necessarily. If I recall correctly, there are two geographically distinct varieties associated with African Sleeping...
Just thinking out loud, I wonder what happens to your gut microbiome when you are suddenly exposed to foreign food, water, and whatever else might...
Has anyone else noticed that a fair number of folks report travel to undeveloped countries before developing ME? It's entirely anecdotal, but...
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