Search results

I have no relevant research/medical background, but found interesting the claim that macrophages with the m.5019A>G mt-tRNAAla mutation exhibit an early "interferon burst" via a specific signaling pathway, which is then followed by a delayed phase driven by the release of mitochondrial DNA and...

Abstract Impaired mitochondrial bioenergetics in macrophages promotes hyperinflammatory cytokine responses, but whether inherited mtDNA mutations drive similar phenotypes is unknown. Here, we profiled macrophages harbouring a heteroplasmic mitochondrial tRNAAla mutation (m.5019A>G) to address...

This seems very worthwhile to me: "To address current knowledge gaps, future research should consider repeated mucosal sampling, combined virus detection methods including metagenomic sequencing, and comprehensive immune and symptom tracking to clarify whether mucosal viral activity is a...

I'm completely unqualified (no medical or research training), but my instinct says that this nasal study, the Edwards et al paper, and DecodeME can perhaps be interpreted as telling a unified story—namely, that post-infectious chronic illness is likely immune-perpetuated tissue dysfunction...

I really feel this study is onto something. I'm in over my skis in terms of the detail, but would it be fair to say that the nasal epithelium study’s central finding around TNFα and TGFβ Signaling (i.e., TNFα and TGFβ driving pathological changes) is broadly supported by the hypothesis paper...

Thank you Jonathan - and coauthors - for this fascinating paper. I'm especially interested in how this hypothesis could be tested or refined through long-read whole genome sequencing, as in the proposed largescale SequenceME study. I'm not an immunologist or a geneticist but I ran the paper...

Agree!

SequenceME is a collaboration between UoE, AfME and Oxford Nanopore Technologies which aims to conduct whole genome sequencing of 17,000 samples from the DecodeME sample set to look at every location in the 3 billion letter genome. This will go beyond the GWAS (i.e., DecodeME) by enabling...

Good to see some media coverage on this: The medical breakthroughs to watch out for in 2025

Just to note that this study is covered in an article on the landing page of the Financial Times today: Anti-viral protein found to be important long Covid indicator (ft.com)

I found this very interesting - thanks for laying it out so clearly. Do you have thoughts on what an initial/small study could look like to test this idea?

NBC News has just run a story on this: Long Covid study reveals major insights on a potential cause (nbcnews.com)

The Times has an article on this study today, which includes mention of ME. Long Covid changes your muscles, scientists find (thetimes.co.uk) "People with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome, also report suffering from PEM." If someone with more scientific...

Thanks everyone for all the replies and perspectives - useful as always in putting the study's conclusions into context.

On a related note to the studies mentioned above, I wonder if anyone has a view on the clinical trial conducted for laser light therapy in Fibromyalgia that led to FDA approval in October 2022 for FibroLux, a laser-based therapy developed by the US-based firm, Multi Radiance Medical...

Do you know if a recording of this will be made available? Thanks!

Welcome to the forum Audrey and best of luck with your project.

In case useful as background context for those attending, here's the list of all active NIH research projects in ME/CFS that are NOT run out of the mothership in Bethesda, MD: https://reporter.nih.gov/search/6hBR43tYGU6vxH4wMar-OQ/projects?shared=true

Thanks Hutan for these v helpful pointers.

Hello all, this study came onto my radar after reading the following media article on the search for a biomarker and treatments for Long Covid, published yesterday: Long COVID is devastating and far from rare. As infections rise again, why are we still ignoring it? | Salon.com In the media...