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Maybe it’s just me (just kidding, it clearly is just me) but I find your focus on "exercise” for your pubmed search curious. Care to expound upon your choice?

Wow, 3000 papers. Sure sounds like a lot. I don’t know. That’s definitely more than I found via my pubmed search.

My response was to your suggestion that this could be so easily dismissed. I've shared the current Dx criteria which these patients met. The claim that women from a physically active society retain more robust GH response (to what?) than those who are more sedentary makes for a nice anecdote...

Agree that truth is a laudible goal but sometime folklore when unexamined begins to look like truth.

I'm not entirely clear on how you differentiate and which studies to which you are referring. Perhaps much of what is being dismissed is more important than is thought but the schema is faulty.

I didn't raise the question about low activity levels causing low GH response to the GST. I provided the most up to date clinical guidance which does not mention anything about low activity and low GH (but does mention obesity and glucose intolerance - of which there is nothing suggesting it as...

First, with regards to GHD and this study, we are talking about four of eleven subjects/patients identified as hormonally deficient. Throw those four out and you still have a majority of severely ill subjects that were deficient for other hormones. But why throw those four out? Of all the...

That's already been suggested regarding fatigue. I can assure you that is not the case.

Is the interpretation less challenging if you presume that the most severe pituitary/hypothalamic damage might occur over a period of years (with a lot of adaptation and compensation - ablation not so much) and that there could simultaneously be a significant amount of immune/inflammatory...

Thirty subjects is a very small sample and thirteen severe ME/CFS patients even smaller. That said, identifiable and treatable hormonal deficiencies in 11 of those thirteen is a lot of previously unrecognized/untreated dysfunction in this small group. At the least, I would hope that treating...

De Bellis, Montoya, et al. found that GH and IGF-1 were significantly lower in Group 1A. Four (of 13) severe ME/CFS subjects were Dx'd with GHD (1 in 3 to 4).

That sort of significant shift in some aspect of a pt's ME Sx's and/or the severity of a symptom seems to be more common that is widely discussed. I suspect that tracking those sorts of changes has been beyond the resources of ME/CFS researchers without a framework in which to understand what...

This may already be underway. Keep in mind that these ME patients were screened for no prior endocrine diagnoses. They didn't have endocrinologists they were seeing. I know of patients who have made impressive gains when properly Dx'd and Tx'd. There are excellent treatments that are not...

I am not familiar with any suitable alternatives. Dr. De Bellis is the worlds expert on this topic (go take a look on pubmed and at JCEM). One obstacle would be trying to make this argument with a technology that lacks the weight of all the work she has done. You'd likely add at least another...

ALL Thirteen subjects with severe ME were found to have high APA and/or AHA antibodies. Eleven of those 13 had stimulation tests that were positive for central ACTH or GH deficiencies. Two thirds of all MS/CFS subjects were positive for APA and/or AHA. Antibodies are not a sign of actual...

Not sure why you would think this has anything to do with the reasons this study hasn't been done before (I can assure you that it does not - JCEM has not published a single study with CFS as the primary patient group since 2008 - CFS has been dead to endocrinology). All use of animals...

Consider this from the recent APA AHA ME/CFS study by De Bellis and Montoya: "..., a viral aggression toward the CNS causing injury of brain structures was already observed some years ago in patients infected by SARS-CoV, a coronavirus responsible for severe acute respiratory syndrome, leading...