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How many times are they planning to repeat these same old CPET/ICPET studies that always return the same results? Isn't research supposed to be incremental?

And the treatment is? Hard not to stay pessimistic when there are several studies reporting the same thing over and over, but I feel there is no way forward. This one, for example, was from the last year...

Maybe I am missing something, but why is this an hypothesis? We've been taking ICPETs for a while know, both in research and clinical practice. There you get a great profile, not only of lactate byproduct, but the respiration levels itself. But this is all a downstream effect anyway. Question...

I always felt weird how everyone clings to the term "dysautonomia", while it is not well established if the tachycardia is caused by a defective autonomic nervous system, or if it is working correctly, but jsut compensating for defective vasculature. In my case, I am convinced that my OI is...

Anyone in particular? David S. Wishart (https://en.wikipedia.org/wiki/David_S._Wishart) fits this profile and he seems to be getting into this space, at least indirectly. His team collected my blood a couple of months ago for a Long Covid study, which was sent to Canada's national metabolomics...

But I haven't heard many people going for a 2-day CPET. They go for an ICPET instead, which does not require 24 hours. I do not think a repeated EndoPAT test would give you more information than an ICPET does. If you are going to require exertion from the patient anyway, may as well as capture...

If all you need is the absolute proof, wouldn't an ICPET be more valuable than a 2-Day CPET? It is way more telling. I got mine done recently at Boston, but I also inquired some other places before, one of them being Pittsburgh, where you live. They do it at the University of Pittsburgh, here is...

The author does not seem to understand the difference between syndrome and disease.

I am kind of sick of the word "rehabilitation" being thrown around Long Covid. What is that even supposed to mean? They are putting the cart before the horse.

Dr. Systrom is probably the best exercise intolerance expert out there. Very familiar with the concept of PEM. Having consulted myself with him before, I am not surprised with the theme of this paper. He is usually associated with Mestinon, which is his drug of choice, but not everyone talks...

I would not be surprised if this was also connected to GPCR autoantibodies, just like this paper from early this year points out: Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients https://pubmed.ncbi.nlm.nih.gov/35074481/ They did not seem to have a panel for...

Is this the mechanism behind IHHT? That therapy never seemed to gain much interest among ME/CFS patients, not sure why there is a taboo around it.

This thread starts with discussion of the preprint. Now that the research has been published, the thread title has been changed and the abstract posted in post #13 Preprint Multi-omics provide evidence for an anti-inflammatory immune signature and metabolic alterations in patients with Long...

I have been on Urolithin A (500mg/day) for almost a month. Doing it along an incremental exercise program. Plan on sticking on it for a couple more weeks, but not really excited about it. I had no side effects, but felt it underwhelming. It is not their first trial that they fail to meet the...