alpha-synuclein

Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes Hannah Scheiblich; Frederik Eikens; Lena Wischhof; Sabine Opitz; Kay Jüngling; Csaba Cserép; Susanne V. Schmidt; Jessica Lambertz; Tracy Bellande; Balázs Pósfai; Charlotte Geck; Jasper...

α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19 Medical University of Innsbruck Innsbruck, Austria Estimated study completion: 2023-12-31 Brief Summary Loss of the sense of smell is a characteristic feature of COVID-19 and likely related to viral invasion of the olfactory...

Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies Authors Abstract Importance Finding a reliable diagnostic biomarker for the disorders collectively known as synucleinopathies (Parkinson disease [PD], dementia with Lewy bodies [DLB], multiple system...

SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy Wang, Jiannan; Dai, Lijun; Deng, Min; Xiao, Tingting; Zhang, Zhaohui; Zhang, Zhentao The 2019 novel coronavirus disease (COVID-19) is an infectious disease that began...

Title: Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease Authors: Christopher Gibbons, Ningshan Wang 1, Sharika Rajan 1, Drew Kern 1, Jose-Alberto Palma 1, Horacio Kaufmann 1, Roy Freeman 2 Abstract: Background and objectives: Multiple system...

SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein Chesney, Andrew D.; Maiti, Buddhadev; Hansmann, Ulrich H. E. Parkinson’s Disease is accompanied by presence of amyloids in the brain formed of α-synuclein chains. Correlation between COVID-19 and the onset of Parkinson’s...

Researchers discover a potential cause of Parkinson’s disease | University of Helsinki “Our findings are significant, as the cause of Parkinson’s disease has gone unknown despite attempts to identify it throughout the last two centuries. The findings indicate that specific strains of...

Background: A growing body of evidence showed that gut microbiota dysbiosis might be associated with the pathogenesis of Parkinson’s disease (PD). Microbiota-targeted interventions could play a protective role in PD by regulating the gut microbiota-gut-brain axis. Sodium butyrate (NaB) could...

Looking forward The opportunities for further clinical research into autonomic medicine are too numerous to list. However, by pointing to a number of strategic areas, I hope to stimulate thought and catalyze ideas for potential research projects: • Well-designed epidemiologic studies are needed...

Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases of probable Parkinson’s disease. As microglial NLRP3...

Abstract Adenosine triphosphate (ATP) at millimolar levels has recently been implicated in the solubilization of cellular proteins. However, the significance of this high ATP level under physiological conditions and the mechanisms that maintain ATP remain unclear. We herein demonstrated that...

Paywalled—mentions glial activation. https://www.nature.com/articles/s41591-021-01382-x Biomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in the clinic but also to facilitate the development and monitoring of effective disease-modifying therapies. Positron...

In mice. Abstract Objective Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation...

For the abstract of the published paper, go to post #9 Preprint Abstract Myalgic Encephalomyelitis and chronic fatigue syndrome is a multisystem illness characterized with extreme muscle fatigue associated with pain, neurocognitive impairment, and chronic inflammation. Despite intense...

Objective: To report a case series of patients with neuropathic POTS and cutaneous phosphorylated alpha-synuclein (P-SYN) deposition on skin biopsy and compare these to neuropathic POTS patients without P-SYN deposition. Methods: The medical history, physical examination findings, autonomic...