Highlights
A subset of nonsteroidal anti-inflammatory drugs (NSAIDs) activates NRF2
C151 of the chaperone protein KEAP1 is necessary for NRF2 activation by indomethacin
Indomethacin reduces inflammation in endotoxemia and gout models dependent on NRF2
Summary
Nonsteroidal...
My gut wasn't that bad when I got ME. I had a bit of Irritable bowel syndrome, but nothing awful. I don't think my gut was quite right but I 100% didn't have inflammatory bowel disease (IBD).
I later had long term antibiotics for suspected Lyme and subsequently got ulcerative colitis, induced...
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