bh4

Stanford Medicine: Potential Role of Tetrahydrobiopterin Deficiency in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) You are invited to participate in a research study of chronic, unexplained fatigue, which is a kind of fatigue that does not improve with rest. Medically...

Hello I have been working on an ME Hypothesis for the last few years. It describes three types of noradrenergic neuron dysfunction, two of which are mediated by insulin. Of course, there could be more subtypes not suggested in this hypothesis. I have made a video explaining the hypothesis-...

This is the preprint. See post #4 for the published paper Augmentation of Anaerobic Pentose Phosphate Pathway Dysregulates Tetrahydrobiopterin Metabolism in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) Patients with Orthostatic Intolerance: A Pilot Study Sarojini Bulbule, Carl...

As pointed out by others there seems to be a discrepancy as to whether BH4 is high or low in MECFS. High—this study looks legit...

The study expands on a previously-awarded proposal to thoroughly explore the underlying pathophysiology of post exertional malaise (PEM), the hallmark symptom of ME/CFS. LEAD INVESTIGATORS Laurel Crosby, PhD Ronald W. Davis, PhD...

Abstract Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a multisystem chronic illness characterized by severe muscle fatigue, pain, dizziness, and brain fog. Many patients with ME/CFS experience orthostatic intolerance (OI), which is characterized by frequent dizziness...

I am starting a new thread for this topic as it may be important. Apparently Tetrahydrobiopterin (aka BH4) has some very interesting associations to Kynurenine pathway, Nitric Oxide production, EBV and many more. I am tagging @wigglethemouse for the SNPs that i provide : GCH1 s4411417 (Risk...