butyrate

Butyrate Selectively Targets Super-Enhancers and Transcriptional Networks Associated with Human Mast Cell Function Jelle Folkerts; Marjolein J. W. de Bruijn; Wilfred F. J. van IJcken; Rudi W. Hendriks; Ralph Stadhouders Mast cells are key drivers of allergic inflammation. We have previously...

Abstract Gut bacteria-derived metabolites, such as butyrate (BUT), induce T regulatory cells through inhibition of histone deacetylases (HDAC). Natural killer (NK) cells are innate lymphocytes with important effector and regulatory functions; little is known on the effect of BUT on NK cells...

Full title: Gut microbiota in very early systemic sclerosis: the first case-control taxonomic and functional characterisation highlighting an altered butyric acid profile Abstract Objectives In systemic sclerosis (SSc), gastrointestinal involvement is one of the earliest events. We compared...

Spaceflight alters host-gut microbiota interactions Gonzalez, E.; Lee, M. D.; Tierney, B. T.; Lipieta, N.; Flores, P.; Mishra, M.; Beckett, L.; Finkelstein, A.; Mo, A.; Walton, P.; Karouia, F.; Barker, R.; Jansen, R. J.; Green, S. J.; Weging, S.; Kelliher, J.; Singh, N. K.; Bezdan, D.; Galazska...

Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV Irini Sereti; Myrthe L. Verburgh; Jacob Gifford; Alice Lo; Anders Boyd; Eveline Verheij; Aswin Verhoeven; Ferdinand W.N.M. Wit; Maarten F. Schim van der Loeff; Martin Giera...

Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia Francesca Sciarretta; Fabio Zaccaria; Andrea Ninni; Veronica Ceci; Riccardo Turchi; Savina Apolloni; Valerio Chiurchiu; Marta Tiberi; Nadia D'Ambrosi; Silvia...

Background Hydrogen gas (H2) is a common product of carbohydrate fermentation in the human gut microbiome and its accumulation can modulate fermentation. Concentrations of colonic H2 vary between individuals, raising the possibility that H2 concentration may be an important factor...

Full title: The short-chain fatty acid butyrate exerts a specific effect on VE-cadherin phosphorylation and alters the integrity of aortic endothelial cells Short-chain fatty acids (SCFAs) like butyrate (BUT) largely influence vascular integrity and are closely associated with the onset and...

Background: A growing body of evidence showed that gut microbiota dysbiosis might be associated with the pathogenesis of Parkinson’s disease (PD). Microbiota-targeted interventions could play a protective role in PD by regulating the gut microbiota-gut-brain axis. Sodium butyrate (NaB) could...

Abstract Background The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE). Prior studies have demonstrated that the multiple sclerosis gut microbiota can contribute to disease, hence...

Abstract The gut microbiota encodes a broad range of enzymes capable of synthetizing various metabolites, some of which are still uncharacterized. One well-known class of microbiota-derived metabolites are the short-chain fatty acids (SCFAs) such as acetate, propionate, butyrate and valerate...

Abstract Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the development of other allergic...

Abstract The human large intestinal microbiota thrives on dietary carbohydrates that are converted to a range of fermentation products. Short-chain fatty acids (acetate, propionate and butyrate) are the dominant fermentation acids that accumulate to high concentrations in the colon and they...

Abstract Knowledge of the functional roles and interspecies interactions are crucial for improving our understanding of the human intestinal microbiome in health and disease. However, the complexity of the human intestinal microbiome and technical challenges in investigating it pose major...

Introduction The aim of the study was to assess the effectiveness of a patented preparation of sodium butyrate in the triglyceride matrix at reducing clinical symptoms and improving quality of life in patients with irritable bowel syndrome (IBS). Material and methods In this prospective...

Abstract Background: Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear. Objective: To investigate whether gut microbiome composition is linked to post-acute COVID-19 syndrome (PACS), defined as at least one...

Free full text: https://www.sciencedirect.com/science/article/pii/S2049080121010955 Review Can l-carnitine reduce post-COVID-19 fatigue? RoyaVaziri-harami a ParisaDelkash b https://doi.org/10.1016/j.amsu.2021.103145Get rights and content Highlights • The coronavirus disease is a viral...

Full title: Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner In mice. Highlights • Butyrate inhibits the production of TNF-α, IL-6 and IL-12 in macrophages. • Butyrate inhibits NF-κB...

Study now published, see https://www.s4me.info/threads/preprint-deficient-butyrate-producing-capacity-in-the-gut-microbiome-of-me-cfs-patients-is-associated-with-fatigue-symptoms-2021-guo-lipkin-et-al.23117/#post-459929 for abstract and link. Preprint: Deficient butyrate-producing capacity in...

Study now printed, see https://www.s4me.info/threads/preprint-multi-omics-of-host-microbiome-interactions-in-short-and-long-term-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-2021-xiong.23022/#post-459931 for abstract and link Preprint: Multi-omics of host-microbiome interactions in...